skin cryodestruction wounds C-reactive protein ceruloplasmin collagen cryopreservation cryopreserved cord blood serum cryoprobe cryoprotectant cryoprotective solution cryosurgery erythrocytes hyaluronic acid hypotonic shock intra-operative temperature control local cold injury low-temperature exposure low-temperature tissue damage model osmotic resistance oxidative stress placenta extract reactive term skin soft tissues temperature thermography tissue morphology С-реактивний білок С-реактивный белок