Вплив краніоцеребральної гіпотермії та клітинної терапії на стан вегетативної нервової системи щурів

• Datum: 2026
• Hauptverfasser: Lomakin, Ivan, Mamontov, Viacheslav, Kudokotseva, Olga
• Format: Artikel
• Veröffentlicht: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2026
• Schlagworte: краніоцеребральна гіпотермія; кріоконсервовані ядровмісні клітини кордової крові; варіабельність серцевого ритму; артеріальна гіпертензія; щури
• Online Zugang: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/2196
• Назва журналу: Problems of Cryobiology and Cryomedicine

This study investigated the eff ects of rhythmic craniocerebral hypothermia (rCCH), administration of cryopreserved nucleated cord blood cells (NCBCs), and their combined application on autonomic regulation of heart rate and arterial blood pressure (BP) parameters in 12 month old spontaneously hypertensive rats (SHRs) with arterial hypertension (AH). A relationship was established between AH and autonomic nervous system imbalance. SHRs demonstrated a shift in heart rate variability (HRV) indices toward enhanced sympathetic activity, which may indicate reduced neurohumoral regulation and signs of overstrain and asthenization within central regulatory structures. On day 7 aft er the combined application of rCCH and NCBCs, the adaptive compensatory capacity of the organism increased signifi cantly. Although these eff ects diminished by day 30, they remained higher compared to the use of each method separately. In addition, unlike the independent application of rCCH or NCBCs, their combined use resulted in a reduction of both systolic and diastolic BP. Probl Cryobiol Cryomed. 2026; 36(2): 128—135