Significance of polyene antibiotics in increasing of membrane permeability and in treatment animal and plant infection

• Datum: 2026
• Hauptverfasser: Qasimova, V.Kh., Hasanli, F.V., Karimova, L.R., Kholina, Т.А.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: Kyiv National University of Construction and Architecture 2026
• Schlagworte: polyene antibiotics; dimethyl sulfoxide; amphotericin B; levorin; lipid membranes; membrane permeability; animal and plant infection
• Online Zugang: https://es-journal.in.ua/article/view/358116
• Назва журналу: Environmental safety and natural resources

It is shown that using polyene antibiotics (PA) in combination with dimethyl sulfoxide sharply increase ionic permeability membranes and biological activity of antibiotics. The comparative physical and chemical characteristics of dimethyl sulfoxide and PA is consideration. The effects of a complex interaction and PA examined by the bilayer lipid membranes (BLM). By the method of determine the parameters biological activity of PA it was show that off all the most studied PA promises more effective were amphotericin B and levorin. Results are started according to BLM conduction of cholesterol in the membranes. On the basis of PA developed an ecological model of environmental protection by establishing membrane–active concentration of PA against viral, fungal and bacterial infection for animals and plants. Using polyene antibiotics (PAs) in combination with dimethyl sulfoxide (DMSO) was shown to increase ion permeability of membranes and biological activity of antibiotics sharply. The comparative physical and chemical characteristics of dimethyl sulfoxide and PAs were determined. The effects of a complex relation between PAs and the bilayer lipid membranes (BLM) were studied. The parameters of biological activity of PAs and BLM were determined. It was shown that among all the studied PAs, amphotericin B and levorin were the most effective. Ion permeability of BLM was shown to depend on the concentrations of amphotericin B, levorin and cholesterol. On the basis of PAs, biological active preparations were developed against viral, bacterial and fungal diseases. It has been shown that the used preparation can completely prevent the growth of the Tobacco mosaic virus. It should be especially noted that after treatment with the “Infanvir” preparation the infected plants are not only cured but also regenerated in full. Moreover, the vegetable plants treated with such preparation had 2 times more harvest than the reference ones. It is supposed that the antivirus and antifungal effect of the “Infanvir” preparation is related to their interaction with lipid components of cytoplasmic membranes, causing destruction of the structure of pathogenic microorganism cells.