Estimation of the absorbed doses of synthesized cisplatin with ¹⁹⁵mPt in various organs of animals

• Дата: 2008
• Автори: Dikiy, N.P., Dovbnya, A.N., Lyashko, Y.V., Medvedeva, E.P., Medvedev, D.V., Uvarov, V.L., Gritsan, L.D., Onishchenko, N.I.
• Формат: Стаття
• Мова: English
• Опубліковано: Національний науковий центр «Харківський фізико-технічний інститут» НАН України 2008
• Назва видання: Вопросы атомной науки и техники
• Теми: Применение ускорителей
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/111558
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Estimation of the absorbed doses of synthesized cisplatin with ¹⁹⁵mPt in various organs of animals / N.P. Dikiy, A.N. Dovbnya, Y.V. Lyashko, E.P. Medvedeva, D.V. Medvedev, V.L. Uvarov, L.D. Gritsan, N.I. Onishchenko // Вопросы атомной науки и техники. — 2008. — № 5. — С. 198-202. — Бібліогр.: 8 назв. — англ.

195mPt has been obtained in reaction ¹⁹⁷Au(g,np)¹⁹⁵mPt on the electron linear accelerator with energy 40 MeV and current 10 mA. To produce ¹⁹⁵mPt from a target of gold the extractor such as Kuchera-Shtoly was needed. The following stage of technology consisted in obtaining synthetic cisplatin on a basis ¹⁹⁵mPt. The admixture of activity ¹⁹⁶Au in synthesized cisplatin was 1.4% relatively of the ¹⁹⁵mPt activity. The effective dozes have been measured in various organs of animals after administration of cisplatin containing ¹⁹⁵mPt with activity 13 kBq. It has been shown that effective dozes from ¹⁹⁵mPt cisplatin for various organs were from 0.72 to 0.20 mGy/MBq.