In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes
Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used...
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| Дата: | 2015 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
НТК «Інститут монокристалів» НАН України
2015
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| Назва видання: | Functional Materials |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/119352 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1193522017-06-07T03:03:07Z In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. Characterization and properties Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used as NCs. NCs/dyes complexes formed in aqueous solutions have been characterized. It has been shown that NCs based on GdYVO₄:Eu³⁺ nanoparticles exhibit the most effective accumulation in cells and provide very fast release of the lipophilic cargo (dyes molecules). Lipophilic compound (cholesterol) embedded into the NCs/dyes complexes decreases noticeably the rate of lipophilic dyes release and reduces the affinity of the complex interaction with hepatocytes. GdYVO₄:Eu³⁺ NPs could be used as a nano-scale platform for controlled intracellular delivering of hydrophobic agents. 2015 Article In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. 1027-5495 DOI: http://dx.doi.org/10.15407/fm22.02.199 http://dspace.nbuv.gov.ua/handle/123456789/119352 en Functional Materials НТК «Інститут монокристалів» НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Characterization and properties Characterization and properties |
| spellingShingle |
Characterization and properties Characterization and properties Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes Functional Materials |
| description |
Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used as NCs. NCs/dyes complexes formed in aqueous solutions have been characterized. It has been shown that NCs based on GdYVO₄:Eu³⁺ nanoparticles exhibit the most effective accumulation in cells and provide very fast release of the lipophilic cargo (dyes molecules). Lipophilic compound (cholesterol) embedded into the NCs/dyes complexes decreases noticeably the rate of lipophilic dyes release and reduces the affinity of the complex interaction with hepatocytes. GdYVO₄:Eu³⁺ NPs could be used as a nano-scale platform for controlled intracellular delivering of hydrophobic agents. |
| format |
Article |
| author |
Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. |
| author_facet |
Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. |
| author_sort |
Yefimova, S.L. |
| title |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_short |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_full |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_fullStr |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_full_unstemmed |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_sort |
in vitro study of ncs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| publisher |
НТК «Інститут монокристалів» НАН України |
| publishDate |
2015 |
| topic_facet |
Characterization and properties |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/119352 |
| citation_txt |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. |
| series |
Functional Materials |
| work_keys_str_mv |
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| first_indexed |
2023-10-18T20:34:21Z |
| last_indexed |
2023-10-18T20:34:21Z |
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