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A statistical model for antibody-antigen binding
We discuss a statistical model for antibody-antigen binding. The two macromolecules are assumed to be linked by a number of relatively weak bonds (or groups of correlated bonds) that are assumed to open and close statistically. We use the model for a preliminary analysis of experiments performed in...
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| Main Authors: | , |
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| Language: | English |
| Published: |
Інститут фізики конденсованих систем НАН України
1999
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| Series: | Condensed Matter Physics |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/120398 |
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| Summary: | We discuss a statistical model for antibody-antigen binding. The two macromolecules are assumed to be linked by a number of relatively weak bonds
(or groups of correlated bonds) that are assumed to open and close statistically. We use the model for a preliminary analysis of experiments performed in the Institute of Biophysics at the Johannes Kepler University. In
these experiments the two molecules are brought into contact using an
atomic force microscope; then a prescribed time dependent force is applied to the bond and the distribution of times needed to pull the molecules
completely apart is measured. This quantity is calculated with our model;
its dependence on the model parameters (binding free energies, number
of groups of correlated elementary bonds, force dependence of the binding
free energy) is determined. |
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