Master equation approach to protein folding
The dynamics of two 12-monomer heteropolymers on the square lattice is studied exactly within the master equation approach. The time evolution of the occupancy of the native state is determined. At low temperatures, the median folding time follows the Arrhenius law and is governed by the longest...
Збережено в:
| Дата: | 1999 |
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| Автори: | , , |
| Мова: | English |
| Опубліковано: |
Інститут фізики конденсованих систем НАН України
1999
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| Назва видання: | Condensed Matter Physics |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/120399 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Master equation approach to protein folding / M. Cieplak, M. Henkel, J.R. Banavar // Condensed Matter Physics. — 1999. — Т. 2, № 2(18). — С. 369-378. — Бібліогр.: 17 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | The dynamics of two 12-monomer heteropolymers on the square lattice is
studied exactly within the master equation approach. The time evolution
of the occupancy of the native state is determined. At low temperatures,
the median folding time follows the Arrhenius law and is governed by the
longest relaxation time. For both good and bad folders, significant kinetic
traps appear in the folding funnel and the kinetics of the two kinds of folders
are quite similar. What distinguishes between the good and bad folders are
the differences in their thermodynamic stabilities. |
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