Correlations between molecular parameters of guest substances and their effect on model lipid membranes

Correlations between molecular parameters of guest substances and their effect on model lipid membranes

Effect of guests molecules on phase transitions of model lipid membranes was studied by differential scanning calorimetry. Membranotropic action of guest molecules was estimated from the shift of "gel - liquid crystal" phase transition temperature of lipid membranes. Relationships between...

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Datum:2016
Hauptverfasser: Sadchenko, A.O., Vashchenko, O.V., Kasian, N.A., Budianska, L.V., Lisetski, L.N.
Format: Artikel
Sprache:English
Veröffentlicht: НТК «Інститут монокристалів» НАН України 2016
Schriftenreihe:Functional Materials
Schlagworte:
Characterization and properties
Online Zugang:http://dspace.nbuv.gov.ua/handle/123456789/120623
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Correlations between molecular parameters of guest substances and their effect on model lipid membranes / A.O. Sadchenko, O.V. Vashchenko, N.A. Kasian, L.V. Budianska, L.N. Lisetski // Functional Materials. — 2016. — Т. 23, № 2. — С. 230-235. — Бібліогр.: 31 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-120623
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spelling irk-123456789-1206232017-06-13T03:06:14Z Correlations between molecular parameters of guest substances and their effect on model lipid membranes Sadchenko, A.O. Vashchenko, O.V. Kasian, N.A. Budianska, L.V. Lisetski, L.N. Characterization and properties Effect of guests molecules on phase transitions of model lipid membranes was studied by differential scanning calorimetry. Membranotropic action of guest molecules was estimated from the shift of "gel - liquid crystal" phase transition temperature of lipid membranes. Relationships between membranotropic action and molecular parameters of guest molecules (volume, surface area, dipole moment, anisometry, lipophilicity coefficient, fraction of the polar area, etc.) were examined. For most of the lipophilic substances studied a high linear correlations between membranotropic action and lipophilicity coefficient (r = 0.86), as well as fraction of polar molecular area (r = -0.83) were established. For hydrophilic substances such correlations were not found. For groups of substances with similar chemical nature (glycerol derivatives, ammonium compounds), high linear correlations (r > 0.8) were established between membranotropic action and such molecular parameters as surface area, volume, dipole moment. 2016 Article Correlations between molecular parameters of guest substances and their effect on model lipid membranes / A.O. Sadchenko, O.V. Vashchenko, N.A. Kasian, L.V. Budianska, L.N. Lisetski // Functional Materials. — 2016. — Т. 23, № 2. — С. 230-235. — Бібліогр.: 31 назв. — англ. 1027-5495 DOI: dx.doi.org/10.15407/fm23.02.230 http://dspace.nbuv.gov.ua/handle/123456789/120623 en Functional Materials НТК «Інститут монокристалів» НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Characterization and properties
Characterization and properties
spellingShingle Characterization and properties
Characterization and properties
Sadchenko, A.O.
Vashchenko, O.V.
Kasian, N.A.
Budianska, L.V.
Lisetski, L.N.
Correlations between molecular parameters of guest substances and their effect on model lipid membranes
Functional Materials
description Effect of guests molecules on phase transitions of model lipid membranes was studied by differential scanning calorimetry. Membranotropic action of guest molecules was estimated from the shift of "gel - liquid crystal" phase transition temperature of lipid membranes. Relationships between membranotropic action and molecular parameters of guest molecules (volume, surface area, dipole moment, anisometry, lipophilicity coefficient, fraction of the polar area, etc.) were examined. For most of the lipophilic substances studied a high linear correlations between membranotropic action and lipophilicity coefficient (r = 0.86), as well as fraction of polar molecular area (r = -0.83) were established. For hydrophilic substances such correlations were not found. For groups of substances with similar chemical nature (glycerol derivatives, ammonium compounds), high linear correlations (r > 0.8) were established between membranotropic action and such molecular parameters as surface area, volume, dipole moment.
format Article
author Sadchenko, A.O.
Vashchenko, O.V.
Kasian, N.A.
Budianska, L.V.
Lisetski, L.N.
author_facet Sadchenko, A.O.
Vashchenko, O.V.
Kasian, N.A.
Budianska, L.V.
Lisetski, L.N.
author_sort Sadchenko, A.O.
title Correlations between molecular parameters of guest substances and their effect on model lipid membranes
title_short Correlations between molecular parameters of guest substances and their effect on model lipid membranes
title_full Correlations between molecular parameters of guest substances and their effect on model lipid membranes
title_fullStr Correlations between molecular parameters of guest substances and their effect on model lipid membranes
title_full_unstemmed Correlations between molecular parameters of guest substances and their effect on model lipid membranes
title_sort correlations between molecular parameters of guest substances and their effect on model lipid membranes
publisher НТК «Інститут монокристалів» НАН України
publishDate 2016
topic_facet Characterization and properties
url http://dspace.nbuv.gov.ua/handle/123456789/120623
citation_txt Correlations between molecular parameters of guest substances and their effect on model lipid membranes / A.O. Sadchenko, O.V. Vashchenko, N.A. Kasian, L.V. Budianska, L.N. Lisetski // Functional Materials. — 2016. — Т. 23, № 2. — С. 230-235. — Бібліогр.: 31 назв. — англ.
series Functional Materials
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first_indexed 2023-10-18T20:37:30Z
last_indexed 2023-10-18T20:37:30Z
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