The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation bet...
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| Дата: | 2014 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут клітинної біології та генетичної інженерії НАН України
2014
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| Назва видання: | Цитология и генетика |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/126634 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility / X. Liu, J. Xu, C.D. Hu, Z.L. Pan, Y.C. Zhang // Цитология и генетика. — 2014. — Т. 48, № 3. — С. 24-29. — Бібліогр.: 36 назв. — англ. |
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irk-123456789-1266342017-11-30T03:02:55Z The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility Liu, X. Xu, J. Hu, C.D. Pan, Z.L. Zhang, Y.C. Оригинальные работы Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA. Толл-подобные рецепторы (TLRs) играют важную роль в индукции и регуляции врожденной иммунной системы или адаптивных иммунных ответах. Показано, что что генетическая изменчивость TLRs человека связана с ревматоидным артритом (РА). Целью настоящей работы было изучение корреляций между однонуклеотидным полиморфизмом в сигнальной трансдукции TLRs и генами предрасположенности к РА. G-тип IL-1RAP rs766442 могут быть генами, предохраняющими от РА, в то время как аллели T-типа IL-6R rs11265618 и IL-1RAP rs766442 могут быть генами чувствительности к РА. Изучение полиморфизма нуклеиновых кислот в сигнальном пути TLRs может внести вклад в выявление участия генов в механизмах приступов РА, раннюю диагностику и лечение РА. The study was supported by Shandong Province young scientist in incentive fund (Grant № 2006BS03018) and National Natural Science Foundation of China (Grant № 30801025). 2014 Article The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility / X. Liu, J. Xu, C.D. Hu, Z.L. Pan, Y.C. Zhang // Цитология и генетика. — 2014. — Т. 48, № 3. — С. 24-29. — Бібліогр.: 36 назв. — англ. 0564-3783 DOI: 10.3103/S0095452714030074 http://dspace.nbuv.gov.ua/handle/123456789/126634 en Цитология и генетика Інститут клітинної біології та генетичної інженерії НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Оригинальные работы Оригинальные работы |
| spellingShingle |
Оригинальные работы Оригинальные работы Liu, X. Xu, J. Hu, C.D. Pan, Z.L. Zhang, Y.C. The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility Цитология и генетика |
| description |
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA. |
| format |
Article |
| author |
Liu, X. Xu, J. Hu, C.D. Pan, Z.L. Zhang, Y.C. |
| author_facet |
Liu, X. Xu, J. Hu, C.D. Pan, Z.L. Zhang, Y.C. |
| author_sort |
Liu, X. |
| title |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| title_short |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| title_full |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| title_fullStr |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| title_full_unstemmed |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| title_sort |
relationship between snps in the genes of tlr signal transduction pathway downstream elements and rheumatoid arthritis susceptibility |
| publisher |
Інститут клітинної біології та генетичної інженерії НАН України |
| publishDate |
2014 |
| topic_facet |
Оригинальные работы |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/126634 |
| citation_txt |
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility / X. Liu, J. Xu, C.D. Hu, Z.L. Pan, Y.C. Zhang // Цитология и генетика. — 2014. — Т. 48, № 3. — С. 24-29. — Бібліогр.: 36 назв. — англ. |
| series |
Цитология и генетика |
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