About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts
In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, er...
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| Видавець: | Національний антарктичний науковий центр МОН України |
|---|---|
| Дата: | 2009 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Національний антарктичний науковий центр МОН України
2009
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| Назва видання: | Український антарктичний журнал |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/128581 |
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| Цитувати: | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. |
Репозиторії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1285812018-01-12T03:03:03Z About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. Біологічні дослідження In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, erosions and hemorrhages. Melanin in dose 5 mg/kg defended gastric mucosa against development of injuries evoked by stress. Irreversible selective antagonist of peroxisome proliferator-activated receptors gamma GW9662 in dose 1 mg/kg removed the cytoprotective action of melanin on formation of stress injuries. We concluded that antistress action of melanin on gastric mucosa in rats completely or partially is governed by activation of peroxisome proliferator-activated receptors gamma. 2009 Article About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. 1727-7485 http://dspace.nbuv.gov.ua/handle/123456789/128581 576.311.31:(612.015.4:582.282.23):(612.063:612.33)(1-923.3) en Український антарктичний журнал Національний антарктичний науковий центр МОН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Біологічні дослідження Біологічні дослідження |
| spellingShingle |
Біологічні дослідження Біологічні дослідження Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts Український антарктичний журнал |
| description |
In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, erosions and hemorrhages. Melanin in dose 5 mg/kg defended gastric mucosa against development of injuries evoked by stress. Irreversible selective antagonist of peroxisome proliferator-activated receptors gamma GW9662 in dose 1 mg/kg removed the cytoprotective action of melanin on formation of stress injuries. We concluded that antistress action of melanin on gastric mucosa in rats completely or partially is governed by activation of peroxisome proliferator-activated receptors gamma. |
| format |
Article |
| author |
Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. |
| author_facet |
Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. |
| author_sort |
Kukharskyy, V.M. |
| title |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_short |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_full |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_fullStr |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_full_unstemmed |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_sort |
about involvement of peroxisome proliferator-activated receptor gamma in mechanism of antiulcer action of melanin isolated from antarctic yeasts |
| publisher |
Національний антарктичний науковий центр МОН України |
| publishDate |
2009 |
| topic_facet |
Біологічні дослідження |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/128581 |
| citation_txt |
About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. |
| series |
Український антарктичний журнал |
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