Experimental bladder carcinogenesis – rodent models
Several rodent models of bladder cancer development have been established. The aim of this review article is to provide a critical assessment of different animal models available for the study of bladder carcinogenesis, its chemoprevention and therapy. All, except for transgenic and knockout anima...
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Видавець: | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Дата: | 2006 |
Автори: | , , , |
Формат: | Стаття |
Мова: | English |
Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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Назва видання: | Experimental Oncology |
Теми: | |
Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/134155 |
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Цитувати: | Experimental bladder carcinogenesis – rodent models / P.A. Oliveira, A. Colaco,P. L.F. De la Cruz, C. Lopes // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 2-11. — Бібліогр.: 99 назв. — англ. |
Репозиторії
Digital Library of Periodicals of National Academy of Sciences of UkraineРезюме: | Several rodent models of bladder cancer development have been established. The aim of this review article is to provide a critical
assessment of different animal models available for the study of bladder carcinogenesis, its chemoprevention and therapy. All, except
for transgenic and knockout animals, require 8–12 months experimental periods in order to generate a high yield of neoplasias.
Spontaneous bladder tumor models are extremely rare. The significance of the results from animal experiments is dependent upon the
selection of a suitable animal model. There are no rules regarding the choice of a model, it is however very useful to have knowledge
of relevant comparative medical aspects concerning this subject. We describe chemical carcinogens most commonly used to induce
bladder cancer, pellet implantation and urinary calculi, agents that promote bladder cancer, and irradiation. We also evaluated
other tools such as cell cultures, tumor implantation and transgenic models for bladder cancer, that have been developed to study
the process. The review considers how several imaging techniques can be applied to study rodent bladder carcinogenesis. |
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