Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005)
Aim: The question as to whether the incidence of leukemias and malignant lymphomas among the Chernobyl clean-up workers increased in 20 years after the catastrophe is still a point of much controversy. Precise diagnosis of the main forms of hematopoietic malignancies according to FAB classification...
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| Дата: | 2006 |
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| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/134530 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) / D. Gluzman, N. Imamura, L. Sklyarenko, V. Nadgornaya, M. Zavelevich, V. Machilo // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 60-63. — Бібліогр.: 18 назв. — англ. |
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Original contributions Original contributions |
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Original contributions Original contributions Gluzman, D. Imamura, N. Sklyarenko, L. Nadgornaya, V. Zavelevich, M. Machilo, V. Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) Experimental Oncology |
| description |
Aim: The question as to whether the incidence of leukemias and malignant lymphomas among the Chernobyl clean-up workers increased in 20 years after the catastrophe is still a point of much controversy. Precise diagnosis of the main forms of hematopoietic malignancies according to FAB classification and new WHO classification and comparison of these data with that in the general population will be helpful in estimating the relative contribution of the radiation factor to the overall incidence of such pathologies. Patients and methods: The data on 218 consecutive cases of malignant diseases of hematopoietic and lymphoid tissues in Chernobyl clean-up workers diagnosed in 1996–2005 are given in comparison with the data of 2697 consecutive patients of general population of the same age group. The morphology and cytochemistry of bone marrow and peripheral blood cells were studied. Immunocytochemical techniques (APAAP, LSAB-AP) and the broad panel of monoclonal antibodies to lineage specific and differentiation antigens of leukocytes were employed for immunophenotyping leukemic cells. Results: Various types of oncohematological diseases developing 10–20 years after Chernobyl accident were registered in a group of clean-up workers under study including myelodysplastic syndromes (MDS), acute leukemias (ALL and AML), chronic myelogenous leukemia (CML) and other chronic myeloproliferative diseases, chronic lymphocytic leukemia (B-CLL) and other chronic lymphoproliferative diseases of B and T cell origin. MDS percentage among patients of clean-up workers group tended to exceed MDS percentage in the group of patients representing the general population examined at the same period (4.58 vs. 3.70%). Among 34 AML cases, leukemia was preceded by MDS in seven patients. The relative contribution of CML to the total number of clean-up workers with leukemia was higher than the corresponding percentage value in general population examined at the same period (9.17 vs. 6.59%). B-CLL was a predominant form of hematopoietic malignancies in clean-up workers under study (25.68%). Nevertheless, B-CLL percentage in patients of clean-up workers group did not differ significantly from that in the patients of general population. The multiple myeloma percentage (7.79%) in the group of patients belonging to clean-up workers in our study turned out to be twice as much as in the patients of general population (4.0%). Conclusion: The verified diagnosis of tumors of hematopoietic and lymphoid tissue according to modern classification (EGIL, WHO) could be the prerequisite for further molecular genetic and analytical epidemiology study of leukemias that may be related to Chernobyl NPP accident consequences. |
| format |
Article |
| author |
Gluzman, D. Imamura, N. Sklyarenko, L. Nadgornaya, V. Zavelevich, M. Machilo, V. |
| author_facet |
Gluzman, D. Imamura, N. Sklyarenko, L. Nadgornaya, V. Zavelevich, M. Machilo, V. |
| author_sort |
Gluzman, D. |
| title |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| title_short |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| title_full |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| title_fullStr |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| title_full_unstemmed |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| title_sort |
patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/134530 |
| citation_txt |
Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) /
D. Gluzman, N. Imamura, L. Sklyarenko, V. Nadgornaya, M. Zavelevich, V. Machilo // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 60-63. — Бібліогр.: 18 назв. — англ. |
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Experimental Oncology |
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2023-10-18T21:08:57Z |
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2023-10-18T21:08:57Z |
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irk-123456789-1345302018-06-14T03:06:39Z Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) Gluzman, D. Imamura, N. Sklyarenko, L. Nadgornaya, V. Zavelevich, M. Machilo, V. Original contributions Aim: The question as to whether the incidence of leukemias and malignant lymphomas among the Chernobyl clean-up workers increased in 20 years after the catastrophe is still a point of much controversy. Precise diagnosis of the main forms of hematopoietic malignancies according to FAB classification and new WHO classification and comparison of these data with that in the general population will be helpful in estimating the relative contribution of the radiation factor to the overall incidence of such pathologies. Patients and methods: The data on 218 consecutive cases of malignant diseases of hematopoietic and lymphoid tissues in Chernobyl clean-up workers diagnosed in 1996–2005 are given in comparison with the data of 2697 consecutive patients of general population of the same age group. The morphology and cytochemistry of bone marrow and peripheral blood cells were studied. Immunocytochemical techniques (APAAP, LSAB-AP) and the broad panel of monoclonal antibodies to lineage specific and differentiation antigens of leukocytes were employed for immunophenotyping leukemic cells. Results: Various types of oncohematological diseases developing 10–20 years after Chernobyl accident were registered in a group of clean-up workers under study including myelodysplastic syndromes (MDS), acute leukemias (ALL and AML), chronic myelogenous leukemia (CML) and other chronic myeloproliferative diseases, chronic lymphocytic leukemia (B-CLL) and other chronic lymphoproliferative diseases of B and T cell origin. MDS percentage among patients of clean-up workers group tended to exceed MDS percentage in the group of patients representing the general population examined at the same period (4.58 vs. 3.70%). Among 34 AML cases, leukemia was preceded by MDS in seven patients. The relative contribution of CML to the total number of clean-up workers with leukemia was higher than the corresponding percentage value in general population examined at the same period (9.17 vs. 6.59%). B-CLL was a predominant form of hematopoietic malignancies in clean-up workers under study (25.68%). Nevertheless, B-CLL percentage in patients of clean-up workers group did not differ significantly from that in the patients of general population. The multiple myeloma percentage (7.79%) in the group of patients belonging to clean-up workers in our study turned out to be twice as much as in the patients of general population (4.0%). Conclusion: The verified diagnosis of tumors of hematopoietic and lymphoid tissue according to modern classification (EGIL, WHO) could be the prerequisite for further molecular genetic and analytical epidemiology study of leukemias that may be related to Chernobyl NPP accident consequences. Цель: вопрос о количественных показателях заболеваемости лейкозами и злокачественных лимфомах у ликвидаторов аварии на ЧАЭС, спустя 20 лет после Чернобыльской катастрофы, остается невыясненным. Диагностика этих заболеваний в соответствии с ФАБ- классификацией и новой классификацией ВОЗ, сравнение полученных данных с данными лиц, не подвергавшимся воздействию ионизирующего излучения, является необходимой предпосылкой для разрешения этого вопроса и выяснения роли радиационного фактора в развитии злокачественных заболеваний кроветворной и лимфоидной тканей. Методы: проанализированы 218 последовательных случаев лейкозов, диагностированных в 1996–2005 гг. у ликвидаторов аварии на ЧАЭС, по сравнению с группой лиц того же возраста, которые не подвергались воздействию излучения (2697 больных). Диагностику лейкозов осуществляли на основе морфологического и цитохимического изучения мазков крови и костного мозга, иммунофенотипирования лейкемических клеток с использованием широкой панели моноклональных антител к линейноспецифическим и дифференцировочным антигенам лейкоцитов. Результаты: спустя 10–20 лет после Чернобыльской катастрофы у ликвидаторов аварии на ЧАЭС выявлены различные формы онкогематологических заболеваний, включая миелодиспластические синдромы (МДС), острые лейкозы (ОЛЛ и ОМЛ), хронический миелолейкоз (ХМЛ) и другие миелопролиферативные заболевания, В-клеточный хронический лимфолейкоз (В-ХЛЛ) и другие лимфопролиферативные процессы В- и Т-клеточной природы. Установлена более высокая частота МДС в группе ликвидаторов по сравнению с группой лиц, не подвергавшихся воздействию излучения (4,58 и 3,70% соответственно). У 7 из 34 больных с ОМЛ в группе ликвидаторов заболевание развилось на фоне предшествующего МДС. Более высокой в этой группе была и заболеваемость ХМЛ (9,17 в сравнении с 6,59% в контрольной группе). В-ХЛЛ был преобладающей формой гемобластозов у ликвидаторов в целом, однако не было установлено существенных различий в частоте развития этого заболевания в сравниваемых группах. У ликвидаторов аварии на ЧАЭС почти в два раза чаще, чем у населения в целом, диагностировалась множественная миелома (7,79 в сравнении с 4,0%). Выводы: представленные данные могут служить основой для проведения последующих молекулярно-генетических и эпидемиологических исследований при основных формах гемобластозов, индуцируемых при действии ионизирующей радиации. 2006 Article Patterns of hematological malignancies in chernobyl clean-up workers (1996–2005) / D. Gluzman, N. Imamura, L. Sklyarenko, V. Nadgornaya, M. Zavelevich, V. Machilo // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 60-63. — Бібліогр.: 18 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/134530 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |