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Cell-cell contact mediated signalling — no fear of contact

Cell-cell contact mediated signalling — no fear of contact

Cancer research with sole focus on the cancer cell and possibly growth factors cannot faithfully reproduce the environmental interaction, such as adhesion of tumor cells to e.g. stromal cells, which may determine the response of these tumors to therapy. Methodologically cell adhesion studies are oft...

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Main Authors: Schmidmaier, R., Baumann, P., Meinhardt, G.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
Series:Experimental Oncology
Subjects:
Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/134534
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spelling irk-123456789-1345342018-06-14T03:06:11Z Cell-cell contact mediated signalling — no fear of contact Schmidmaier, R. Baumann, P. Meinhardt, G. Original contributions Cancer research with sole focus on the cancer cell and possibly growth factors cannot faithfully reproduce the environmental interaction, such as adhesion of tumor cells to e.g. stromal cells, which may determine the response of these tumors to therapy. Methodologically cell adhesion studies are often difficult since complete but careful detachment is the prerequisite for most signal transduction assays. We describe for the first time an alternative method for the co-incubation of multiple myeloma cells on long term primary bone marrow stromal cultures using the bone marrow stromal cell line HS-5. The methods are precisely described, advantages and disadvantages are discussed, and troubleshooting advises are given. Исследования роста опухолевых клеток in vitro не отражают многих факторов (взаимодействие клеток с окружающей средой, их адгезию к клеткам стромы), которые в свою очередь могут определять чувствительность опухоли к терапии. Методологически изучение клеточной адгезии часто бывает затруднено, так как разделение клеток является основой большинства методик по изучению передачи сигнала. Впервые описан альтернативный метод ко-культивирования клеток множественной миеломы с клетками стромы линии HS-5, полученных из клеток костного мозга. Приведено подробное описание, преимущества и недостатки этого метода с детальными техническими рекомендациями. 2006 Article Cell-cell contact mediated signalling — no fear of contact / R. Schmidmaier, P. Baumann, G. Meinhardt // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 12–15. — Бібліогр.: 7 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/134534 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Schmidmaier, R.
Baumann, P.
Meinhardt, G.
Cell-cell contact mediated signalling — no fear of contact
Experimental Oncology
description Cancer research with sole focus on the cancer cell and possibly growth factors cannot faithfully reproduce the environmental interaction, such as adhesion of tumor cells to e.g. stromal cells, which may determine the response of these tumors to therapy. Methodologically cell adhesion studies are often difficult since complete but careful detachment is the prerequisite for most signal transduction assays. We describe for the first time an alternative method for the co-incubation of multiple myeloma cells on long term primary bone marrow stromal cultures using the bone marrow stromal cell line HS-5. The methods are precisely described, advantages and disadvantages are discussed, and troubleshooting advises are given.
format Article
author Schmidmaier, R.
Baumann, P.
Meinhardt, G.
author_facet Schmidmaier, R.
Baumann, P.
Meinhardt, G.
author_sort Schmidmaier, R.
title Cell-cell contact mediated signalling — no fear of contact
title_short Cell-cell contact mediated signalling — no fear of contact
title_full Cell-cell contact mediated signalling — no fear of contact
title_fullStr Cell-cell contact mediated signalling — no fear of contact
title_full_unstemmed Cell-cell contact mediated signalling — no fear of contact
title_sort cell-cell contact mediated signalling — no fear of contact
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2006
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/134534
citation_txt Cell-cell contact mediated signalling — no fear of contact / R. Schmidmaier, P. Baumann, G. Meinhardt // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 12–15. — Бібліогр.: 7 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT schmidmaierr cellcellcontactmediatedsignallingnofearofcontact
AT baumannp cellcellcontactmediatedsignallingnofearofcontact
AT meinhardtg cellcellcontactmediatedsignallingnofearofcontact
first_indexed 2023-10-18T21:08:57Z
last_indexed 2023-10-18T21:08:57Z
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