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Amplification and co-regulators of androgen receptor gene in prostate cancer

Amplification and co-regulators of androgen receptor gene in prostate cancer

Prostate cancer isthe second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group ofsteroid hormones that include testosterone and its more active metabolite dihydrotestosterone. Most prostate cancers are androgen-d...

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Bibliographic Details
Main Authors: Golias, Ch., Iliadis, I., Peschos, D., Charalabopoulos, K.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Series:Experimental Oncology
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Online Access:http://dspace.nbuv.gov.ua/handle/123456789/134927
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Summary:Prostate cancer isthe second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group ofsteroid hormones that include testosterone and its more active metabolite dihydrotestosterone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed.

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