Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers

Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers

Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression...

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Бібліографічні деталі
Дата:2009
Автори: Buchynska, L.G., Iurchenko, N.P., Grinkevych, V.M., Nesina, I.P., Chekhun, S.V., Svintsitsky, V.S.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/134930
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1349302018-06-15T03:03:22Z Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers Buchynska, L.G. Iurchenko, N.P. Grinkevych, V.M. Nesina, I.P. Chekhun, S.V. Svintsitsky, V.S. Original contributions Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression was performed on serous ovarian cancer (OC) tissue samples from 81 OC patients. Results: Serous OC is characterised by high proliferative activity and increased expression of steroid hormone receptors compared to nontransfomed ovarian surface epithelium. It has been shown that ER and PR expression levels depend on tumor histologic grade and the stage of the disease, and are variable between tumors of the same grade. The ER and PR expression levels correlate with OC patients’ survival. Conclusion: Proliferative activity and steroid hormone receptor status along with clinical and morphological characteristics of serous OC possess prognostic significance and may be used for evaluation of the disease course 2009 Article Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/134930 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
Experimental Oncology
description Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression was performed on serous ovarian cancer (OC) tissue samples from 81 OC patients. Results: Serous OC is characterised by high proliferative activity and increased expression of steroid hormone receptors compared to nontransfomed ovarian surface epithelium. It has been shown that ER and PR expression levels depend on tumor histologic grade and the stage of the disease, and are variable between tumors of the same grade. The ER and PR expression levels correlate with OC patients’ survival. Conclusion: Proliferative activity and steroid hormone receptor status along with clinical and morphological characteristics of serous OC possess prognostic significance and may be used for evaluation of the disease course
format Article
author Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
author_facet Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
author_sort Buchynska, L.G.
title Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_short Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_full Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_fullStr Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_full_unstemmed Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_sort expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/134930
citation_txt Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ.
series Experimental Oncology
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AT nesinaip expressionoftheestrogenandprogesteronereceptorsasprognosticfactorinserousovariancancers
AT chekhunsv expressionoftheestrogenandprogesteronereceptorsasprognosticfactorinserousovariancancers
AT svintsitskyvs expressionoftheestrogenandprogesteronereceptorsasprognosticfactorinserousovariancancers
first_indexed 2023-10-18T21:10:32Z
last_indexed 2023-10-18T21:10:32Z
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