Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice
Aim: It has been shown previously that chronic social defeat stress produces development ofstrong anxiety and increases intensity of experimental metastasis in the losers in comparison with the winners and control mice. The question was: isit possible to decrease the number ofmetastases inthe lose...
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| Дата: | 2009 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/135107 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice / V.I. Kaledin, S.I. llnitskaya, V.P. Nikolin, N.A. Popova, D.A. Smagin, N.N. Kudryavtseva // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 62–64. — Бібліогр.: 18 назв. — англ. |
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irk-123456789-1351072018-06-15T03:10:17Z Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice Kaledin, V.I. llnitskaya, S.I. Nikolin, V.P. Popova, N.A. Smagin, D.A. Kudryavtseva, N.N. Short communications Aim: It has been shown previously that chronic social defeat stress produces development ofstrong anxiety and increases intensity of experimental metastasis in the losers in comparison with the winners and control mice. The question was: isit possible to decrease the number ofmetastases inthe losers by chronic or acute diazepam treatment. Materials and Methods: Sensory contact model was used for generating male mice with repeated experience of social victories or defeats in daily agonistic interactions. Tumor cells of Lewis Lung Carcinoma (LLC) were injected into the tail vein of animals after 10 days of agonistic interactions. Then mice were treated acutely or chronically (7 days) with diazepam (1 mg/kg, i. p). Number ofmetastases in the lung was calculated in 16 days after tumor cell transplantation. Results: Diazepam decreased the number of LLC metastases in anxious losers, whereas in the winners and control mice, without anxiety state, diazepam was ineffective. Conclusion: Well-known anxiolytic diazepam may decrease intensity of metastasis in anxious mice. 2009 Article Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice / V.I. Kaledin, S.I. llnitskaya, V.P. Nikolin, N.A. Popova, D.A. Smagin, N.N. Kudryavtseva // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 62–64. — Бібліогр.: 18 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135107 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Kaledin, V.I. llnitskaya, S.I. Nikolin, V.P. Popova, N.A. Smagin, D.A. Kudryavtseva, N.N. Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice Experimental Oncology |
| description |
Aim: It has been shown previously that chronic social defeat stress produces development ofstrong anxiety and increases intensity of experimental
metastasis in the losers in comparison with the winners and control mice. The question was: isit possible to decrease the number
ofmetastases inthe losers by chronic or acute diazepam treatment. Materials and Methods: Sensory contact model was used for generating
male mice with repeated experience of social victories or defeats in daily agonistic interactions. Tumor cells of Lewis Lung Carcinoma
(LLC) were injected into the tail vein of animals after 10 days of agonistic interactions. Then mice were treated acutely or chronically
(7 days) with diazepam (1 mg/kg, i. p). Number ofmetastases in the lung was calculated in 16 days after tumor cell transplantation. Results:
Diazepam decreased the number of LLC metastases in anxious losers, whereas in the winners and control mice, without anxiety state,
diazepam was ineffective. Conclusion: Well-known anxiolytic diazepam may decrease intensity of metastasis in anxious mice. |
| format |
Article |
| author |
Kaledin, V.I. llnitskaya, S.I. Nikolin, V.P. Popova, N.A. Smagin, D.A. Kudryavtseva, N.N. |
| author_facet |
Kaledin, V.I. llnitskaya, S.I. Nikolin, V.P. Popova, N.A. Smagin, D.A. Kudryavtseva, N.N. |
| author_sort |
Kaledin, V.I. |
| title |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| title_short |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| title_full |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| title_fullStr |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| title_full_unstemmed |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| title_sort |
limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2009 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/135107 |
| citation_txt |
Limiting effect of diazepam on lewis lung carcinoma metastasis in anxious male mice / V.I. Kaledin, S.I. llnitskaya, V.P. Nikolin, N.A. Popova, D.A. Smagin, N.N. Kudryavtseva // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 62–64. — Бібліогр.: 18 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:11:14Z |
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