Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer
Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene encodes a DNA gly...
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| Дата: | 2009 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/135113 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. |
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irk-123456789-1351132018-06-15T03:10:07Z Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. Short communications Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene encodes a DNA glycosylase that can initiate the base excision repair (BER) pathway and prevent G:C > T:A transversion by excising adenine mispaired with 8-hydroxyguanine produced by reactive oxygen species (ROS). Aim: to perform a case-control study to test the association between polymorphism in the MUTYH gene: Tyr165Cys and head and neck cancer risk progression. Methods: Genotypes were determined in DNA from peripheral blood lymphocytes of 193 patients (among them 97 subjects with precancerous hyperplastic laryngeal lesions and 96 subjects with head and neck cancer) and 140 age, sex and ethnic-matched cancer-free controls by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Results: We found an association between head and neck cancer risk and the Tyr165Tyr variant of the MUTYH gene (OR 2.18; 95% CI 1.19–3.97). For Tyr165Tyr genotype we also observed positive correlation with cancer progression assessed by tumor size (OR 4.56; 95% CI 1.60–12.95). We did not observe any correlation between Tyr165Cys polymorphism of MUTYHgene and precancerous hyperplastic laryngeal lesions risk. Conclusion: The Tyr165Tyr polymorphic variant of the MUTYHgene may be associated with head and neck cancer in Polish population. 2009 Article Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135113 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer Experimental Oncology |
| description |
Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC
are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene
encodes a DNA glycosylase that can initiate the base excision repair (BER) pathway and prevent G:C > T:A transversion by excising adenine mispaired
with 8-hydroxyguanine produced by reactive oxygen species (ROS). Aim: to perform a case-control study to test the association between polymorphism
in the MUTYH gene: Tyr165Cys and head and neck cancer risk progression. Methods: Genotypes were determined in DNA from peripheral blood
lymphocytes of 193 patients (among them 97 subjects with precancerous hyperplastic laryngeal lesions and 96 subjects with head and neck cancer)
and 140 age, sex and ethnic-matched cancer-free controls by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Results:
We found an association between head and neck cancer risk and the Tyr165Tyr variant of the MUTYH gene (OR 2.18; 95% CI 1.19–3.97). For
Tyr165Tyr genotype we also observed positive correlation with cancer progression assessed by tumor size (OR 4.56; 95% CI 1.60–12.95). We did
not observe any correlation between Tyr165Cys polymorphism of MUTYHgene and precancerous hyperplastic laryngeal lesions risk. Conclusion:
The Tyr165Tyr polymorphic variant of the MUTYHgene may be associated with head and neck cancer in Polish population. |
| format |
Article |
| author |
Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. |
| author_facet |
Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. |
| author_sort |
Sliwinski, T. |
| title |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_short |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_full |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_fullStr |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_full_unstemmed |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_sort |
polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2009 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/135113 |
| citation_txt |
Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. |
| series |
Experimental Oncology |
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