Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance

Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance

Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes...

Повний опис

Збережено в:
Бібліографічні деталі
Дата:2009
Автори: Xu, X., Yuan, G., Liu, W., Zhang, Y., Chen, W.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/135696
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-135696
record_format dspace
spelling irk-123456789-1356962018-06-16T03:11:25Z Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. Original contributions Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. 2009 Article Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135696 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Xu, X.
Yuan, G.
Liu, W.
Zhang, Y.
Chen, W.
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
Experimental Oncology
description Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis.
format Article
author Xu, X.
Yuan, G.
Liu, W.
Zhang, Y.
Chen, W.
author_facet Xu, X.
Yuan, G.
Liu, W.
Zhang, Y.
Chen, W.
author_sort Xu, X.
title Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
title_short Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
title_full Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
title_fullStr Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
title_full_unstemmed Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
title_sort expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/135696
citation_txt Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT xux expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance
AT yuang expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance
AT liuw expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance
AT zhangy expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance
AT chenw expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance
first_indexed 2023-10-18T21:12:58Z
last_indexed 2023-10-18T21:12:58Z
_version_ 1796152231298334720

Схожі ресурси