Nuclear receptors and their role in epstein — barr virus induced b cell transformation

• Дата: 2009
• Автори: Yenamandra, S.P., Klein, G., Kashuba, E.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Назва видання: Experimental Oncology
• Теми: Reviews
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/135697
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ.

Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these receptors in B cell transformation upon EBV infection based on the literature data.