Nuclear receptors and their role in epstein — barr virus induced b cell transformation
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs)...
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| Дата: | 2009 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/135697 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
Репозитарії
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irk-123456789-1356972018-06-16T03:07:09Z Nuclear receptors and their role in epstein — barr virus induced b cell transformation Yenamandra, S.P. Klein, G. Kashuba, E. Reviews Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these receptors in B cell transformation upon EBV infection based on the literature data. 2009 Article Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135697 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Yenamandra, S.P. Klein, G. Kashuba, E. Nuclear receptors and their role in epstein — barr virus induced b cell transformation Experimental Oncology |
| description |
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells
that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the
constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and
down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these
receptors in B cell transformation upon EBV infection based on the literature data. |
| format |
Article |
| author |
Yenamandra, S.P. Klein, G. Kashuba, E. |
| author_facet |
Yenamandra, S.P. Klein, G. Kashuba, E. |
| author_sort |
Yenamandra, S.P. |
| title |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_short |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_fullStr |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full_unstemmed |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_sort |
nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2009 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/135697 |
| citation_txt |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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| first_indexed |
2023-10-18T21:11:20Z |
| last_indexed |
2023-10-18T21:11:20Z |
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