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Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation

Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation

Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs, that will help to elucidat...

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Main Authors: Yenamandra, S.P., Lundin, A., Arulampalam, V., Yurchenko, M., Pettersson, S., Klein, G., Kashuba, E.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/135700
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spelling irk-123456789-1357002018-06-22T14:51:33Z Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation Yenamandra, S.P. Lundin, A. Arulampalam, V. Yurchenko, M. Pettersson, S. Klein, G. Kashuba, E. Original contributions Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs, that will help to elucidate the mechanism of B cell transformation. Methods: We have compared the nuclear receptor profile in the naïve and EBV-transformed B-lymphocytes, using TaqMan LDA microfluidic card technology. Results: Out of 48 nuclear receptor, 17 showed differential expression at the mRNA level. The expression of 5 genes was elevated in EBV-transformed cells, whereas 12 genes were downregulated in lymphoblastoid cells (LCLs). 7 genes were studied at the protein level; 2 genes were up regulated (Nr2F2 and RARA) and 4 genes were down regulated (ERB, NUR77, PPARG, and VDR) in LCLs. Conclusion: The nuclear receptor profiling on EBV infected B cells showed alterations of nuclear receptors expression at both mRNA and protein levels compared with non infected peripheral blood cells. Further analysis on a possible role of each nuclear receptor in EBV induced cell transformation should be performed. 2009 Article Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation / S.P. Yenamandra, A. Lundin1, V. Arulampalam, M. Yurchenko, S. Pettersson, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 92–96. — Бібліогр.: 23 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135700 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Yenamandra, S.P.
Lundin, A.
Arulampalam, V.
Yurchenko, M.
Pettersson, S.
Klein, G.
Kashuba, E.
Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
Experimental Oncology
description Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs, that will help to elucidate the mechanism of B cell transformation. Methods: We have compared the nuclear receptor profile in the naïve and EBV-transformed B-lymphocytes, using TaqMan LDA microfluidic card technology. Results: Out of 48 nuclear receptor, 17 showed differential expression at the mRNA level. The expression of 5 genes was elevated in EBV-transformed cells, whereas 12 genes were downregulated in lymphoblastoid cells (LCLs). 7 genes were studied at the protein level; 2 genes were up regulated (Nr2F2 and RARA) and 4 genes were down regulated (ERB, NUR77, PPARG, and VDR) in LCLs. Conclusion: The nuclear receptor profiling on EBV infected B cells showed alterations of nuclear receptors expression at both mRNA and protein levels compared with non infected peripheral blood cells. Further analysis on a possible role of each nuclear receptor in EBV induced cell transformation should be performed.
format Article
author Yenamandra, S.P.
Lundin, A.
Arulampalam, V.
Yurchenko, M.
Pettersson, S.
Klein, G.
Kashuba, E.
author_facet Yenamandra, S.P.
Lundin, A.
Arulampalam, V.
Yurchenko, M.
Pettersson, S.
Klein, G.
Kashuba, E.
author_sort Yenamandra, S.P.
title Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
title_short Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
title_full Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
title_fullStr Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
title_full_unstemmed Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
title_sort expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/135700
citation_txt Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation / S.P. Yenamandra, A. Lundin1, V. Arulampalam, M. Yurchenko, S. Pettersson, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 92–96. — Бібліогр.: 23 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:12:59Z
last_indexed 2023-10-18T21:12:59Z
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