Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a...
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| Дата: | 2009 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/135717 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-135717 |
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dspace |
| spelling |
irk-123456789-1357172018-06-16T03:11:02Z Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. Short communications Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy. 2009 Article Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135717 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate Experimental Oncology |
| description |
Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX)
in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells
from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data
were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX
on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot
study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort
of patients could aid in the development of individualized therapies for this class of malignancy. |
| format |
Article |
| author |
Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. |
| author_facet |
Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. |
| author_sort |
Pai, R.B. |
| title |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_short |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_full |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_fullStr |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_full_unstemmed |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_sort |
analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2009 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/135717 |
| citation_txt |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:13:10Z |
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2023-10-18T21:13:10Z |
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