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Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate

Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate

Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a...

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Main Authors: Pai, R.B., Lalitha, R.M., Pai, S.B., Kumaraswamy, S.V., Lalitha, N., Bhargava, M.K.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Series:Experimental Oncology
Subjects:
Short communications
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/135717
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spelling irk-123456789-1357172018-06-16T03:11:02Z Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. Short communications Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy. 2009 Article Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135717 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Pai, R.B.
Lalitha, R.M.
Pai, S.B.
Kumaraswamy, S.V.
Lalitha, N.
Bhargava, M.K.
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Experimental Oncology
description Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy.
format Article
author Pai, R.B.
Lalitha, R.M.
Pai, S.B.
Kumaraswamy, S.V.
Lalitha, N.
Bhargava, M.K.
author_facet Pai, R.B.
Lalitha, R.M.
Pai, S.B.
Kumaraswamy, S.V.
Lalitha, N.
Bhargava, M.K.
author_sort Pai, R.B.
title Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
title_short Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
title_full Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
title_fullStr Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
title_full_unstemmed Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
title_sort analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/135717
citation_txt Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:13:10Z
last_indexed 2023-10-18T21:13:10Z
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