HIF-1 — a big chapter in the cancer tale
Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can activate adaptive cellular responses that c...
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| Дата: | 2016 |
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| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/136134 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. |
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irk-123456789-1361342018-06-16T03:11:32Z HIF-1 — a big chapter in the cancer tale Ajduković, J. Minireview Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resis- and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelialmesenchymal-endothelial transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting. HIF-1 pathway downregulation seems to be promising in future cancer treatment. 2016 Article HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/136134 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Minireview Minireview |
| spellingShingle |
Minireview Minireview Ajduković, J. HIF-1 — a big chapter in the cancer tale Experimental Oncology |
| description |
Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial
for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive
oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resis- and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance
to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelialmesenchymal-endothelial
transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production
of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for
cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting.
HIF-1 pathway downregulation seems to be promising in future cancer treatment. |
| format |
Article |
| author |
Ajduković, J. |
| author_facet |
Ajduković, J. |
| author_sort |
Ajduković, J. |
| title |
HIF-1 — a big chapter in the cancer tale |
| title_short |
HIF-1 — a big chapter in the cancer tale |
| title_full |
HIF-1 — a big chapter in the cancer tale |
| title_fullStr |
HIF-1 — a big chapter in the cancer tale |
| title_full_unstemmed |
HIF-1 — a big chapter in the cancer tale |
| title_sort |
hif-1 — a big chapter in the cancer tale |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2016 |
| topic_facet |
Minireview |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/136134 |
| citation_txt |
HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:13:15Z |
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2023-10-18T21:13:15Z |
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