Neurotropic effects of glycine menthyl ester
The objective of this study was to evaluate toxicity and some pharmacological effects of glycine menthyl ester hydrochloride (2-isopropyl-5-methylcyclohexyl 2-aminoacetate) in animal models.Acute toxicity (LD₅₀ value) in mice was determined for different routes of administration – orally and intrave...
Збережено в:
| Дата: | 2015 |
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| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Фізико-хімічний інститут ім. О.В. Богатського НАН України
2015
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| Назва видання: | Актуальні проблеми транспортної медицини |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/136484 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Neurotropic effects of glycine menthyl ester / M. Nesterkina, I. Kravchenko // Актуальні проблеми транспортної медицини. — 2015. — № 2 (40). — С. 120-123. — Бібліогр.: 9 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | The objective of this study was to evaluate toxicity and some pharmacological effects of glycine menthyl ester hydrochloride (2-isopropyl-5-methylcyclohexyl 2-aminoacetate) in animal models.Acute toxicity (LD₅₀ value) in mice was determined for different routes of administration – orally and intravenously. Anticonvulsant activity was assessed by using pentylenetetrazole and strychnine induced seizures.The sedative and muscle relaxant actions were investigated with open field and rota-rod tests, accordingly. Present findings indicate that menthyl ester of glycine hydrochloride possesses anticonvulsant activity, prolonged sedative action but does not influences the muscle relaxation. |
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