Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats

• Дата: 2006
• Автори: Istomin, Y.P., Laptsevich, T.P., Bizyuk, S.A., Alexandrova, E.N.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Назва видання: Experimental Oncology
• Теми: Original contributions
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/137581
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats / Y.Р. Istomin, T.P. Laptsevich , S.A. Bizyuk, E.N. Alexandrova // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 299-302. — Бібліогр.: 6 назв. — англ.

Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6 — polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min — 5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation. Results: Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6 — polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation. Conclusion: The level of tissue accumulation of chlorin e6 — polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors.