Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats
Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6 — polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min — 5 h, and then tumors were scored for photosensitizer accumulation and tissu...
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| Дата: | 2006 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/137581 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats / Y.Р. Istomin, T.P. Laptsevich , S.A. Bizyuk, E.N. Alexandrova // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 299-302. — Бібліогр.: 6 назв. — англ. |
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irk-123456789-1375812019-05-14T19:10:20Z Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats Istomin, Y.P. Laptsevich, T.P. Bizyuk, S.A. Alexandrova, E.N. Original contributions Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6 — polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min — 5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation. Results: Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6 — polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation. Conclusion: The level of tissue accumulation of chlorin e6 — polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors. Цель: исследовать противоопухолевую эффективность фотодинамической терапии с аппликационной формой комплекса хлорин е6 — поливинилпирролидон. Методы: мазь, содержащую 2 или 5% хлорина е6, наносили на поверхность опухоли Са М-1 крыс на 15 мин–5 ч, а затем определяли накопление фотосенсибилизатора и повреждение опухоли лазерным излучением. Результаты: при местном введении фотосенсибилизатора избирательность накопления хлорина е6 в опухолевых тканях значительно возрастала, по сравнению с внутривенным введением. По противоопухолевой эффективности фотодинамической терапии местное применение комплекса хлорин е6 — поливинилпирролидон не уступало внутривенному введению препарата. Выводы: уровень накопления фотосенсибилизатора в тканях крыс при использовании мазевой формы комплекса хлорин е6 — поливинилпирролидон позволяет проводить как флуоресцентную диагностику, так и фотодинамическую терапию поверхностно расположенных злокачественных опухолей. 2006 Article Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats / Y.Р. Istomin, T.P. Laptsevich , S.A. Bizyuk, E.N. Alexandrova // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 299-302. — Бібліогр.: 6 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137581 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Istomin, Y.P. Laptsevich, T.P. Bizyuk, S.A. Alexandrova, E.N. Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats Experimental Oncology |
| description |
Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6 — polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min — 5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation. Results: Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6 — polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation. Conclusion: The level of tissue accumulation of chlorin e6 — polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors. |
| format |
Article |
| author |
Istomin, Y.P. Laptsevich, T.P. Bizyuk, S.A. Alexandrova, E.N. |
| author_facet |
Istomin, Y.P. Laptsevich, T.P. Bizyuk, S.A. Alexandrova, E.N. |
| author_sort |
Istomin, Y.P. |
| title |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| title_short |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| title_full |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| title_fullStr |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| title_full_unstemmed |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| title_sort |
photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137581 |
| citation_txt |
Photodynamic efficacy of topical application of chlorin e6 — polyvinyl pyrrolidone complex in tumor-bearing rats / Y.Р. Istomin, T.P. Laptsevich , S.A. Bizyuk, E.N. Alexandrova // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 299-302. — Бібліогр.: 6 назв. — англ. |
| series |
Experimental Oncology |
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2023-05-20T17:15:41Z |
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