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Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma

Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma

Aim: To investigate anticancer and immunologic effects of chicken embryonic proteins (CEP) in mice bearing Ehrlich solid carcinoma. Materials and Methods: The study was carried out on male Balb/c mice bearing Ehrlich solid carcinoma. The immunizations were performed after the tumor transplantation....

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Main Authors: Symchych, T.V., Fedosova, N.I., Karaman, O.M., Yevstratieva, L.M., Voyeykova, I.M., Potebnia, H.P.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/137603
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spelling irk-123456789-1376032018-06-18T03:09:50Z Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma Symchych, T.V. Fedosova, N.I. Karaman, O.M. Yevstratieva, L.M. Voyeykova, I.M. Potebnia, H.P. Original contributions Aim: To investigate anticancer and immunologic effects of chicken embryonic proteins (CEP) in mice bearing Ehrlich solid carcinoma. Materials and Methods: The study was carried out on male Balb/c mice bearing Ehrlich solid carcinoma. The immunizations were performed after the tumor transplantation. The immune status was assessed on days 7, 14, 21 and 28 after the tumor challenge. Cytotoxic activity (CAT) of macrophages (Mph), natural killer cells (NK), cytotoxic T-lymphocytes (CTL) and blood serum, as well as the influence of the blood serum on immune cells activity was checked in MTT-assay; Mph’s cytochemical activity was tested in NBT-assay; Ehrlich antigen-specific or CEP-specific antibodies were detected in ELISA-assay; medium size circulating immune complexes (CIC) were detected in reaction of 4.5% polyethylene glycol precipitation. Results: The immunization resulted in tumor growth suppression and significant 25.64% prolongation of the survival time. In both control and immunized mice with transplanted tumors antibodies specific to Ehrlich carcinoma antigens and to CEP were detected, but antibody response was more balanced in the treatment group. In the treatment group both cytochemical and CAT of Mph was moderately activated and well preserved until late stages of tumor development; CAT of NK and CTL remained in the range of the intact mice until day 28 after the tumor transplantation. The immunized mice were well protected from accumulation of CIC and suppressive activity of autologous blood serum. Conclusion: Collectively, our data indicate that CEP can elicit immunomodulating and immunoprotecting effects sufficient to provide tumor growth inhibition. The further elaboration of a xenogeneic anticancer vaccine based on CEP is warranted. 2017 Article Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma / T.V. Symchych, N.I. Fedosova, O.M. Karaman, L.M. Yevstratieva, I.M. Voyeykova, H.P. Potebnia // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 42-48. — Бібліогр.: 27 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137603 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Voyeykova, I.M.
Potebnia, H.P.
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
Experimental Oncology
description Aim: To investigate anticancer and immunologic effects of chicken embryonic proteins (CEP) in mice bearing Ehrlich solid carcinoma. Materials and Methods: The study was carried out on male Balb/c mice bearing Ehrlich solid carcinoma. The immunizations were performed after the tumor transplantation. The immune status was assessed on days 7, 14, 21 and 28 after the tumor challenge. Cytotoxic activity (CAT) of macrophages (Mph), natural killer cells (NK), cytotoxic T-lymphocytes (CTL) and blood serum, as well as the influence of the blood serum on immune cells activity was checked in MTT-assay; Mph’s cytochemical activity was tested in NBT-assay; Ehrlich antigen-specific or CEP-specific antibodies were detected in ELISA-assay; medium size circulating immune complexes (CIC) were detected in reaction of 4.5% polyethylene glycol precipitation. Results: The immunization resulted in tumor growth suppression and significant 25.64% prolongation of the survival time. In both control and immunized mice with transplanted tumors antibodies specific to Ehrlich carcinoma antigens and to CEP were detected, but antibody response was more balanced in the treatment group. In the treatment group both cytochemical and CAT of Mph was moderately activated and well preserved until late stages of tumor development; CAT of NK and CTL remained in the range of the intact mice until day 28 after the tumor transplantation. The immunized mice were well protected from accumulation of CIC and suppressive activity of autologous blood serum. Conclusion: Collectively, our data indicate that CEP can elicit immunomodulating and immunoprotecting effects sufficient to provide tumor growth inhibition. The further elaboration of a xenogeneic anticancer vaccine based on CEP is warranted.
format Article
author Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Voyeykova, I.M.
Potebnia, H.P.
author_facet Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Voyeykova, I.M.
Potebnia, H.P.
author_sort Symchych, T.V.
title Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
title_short Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
title_full Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
title_fullStr Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
title_full_unstemmed Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
title_sort anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2017
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/137603
citation_txt Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing ehrlich solid carcinoma / T.V. Symchych, N.I. Fedosova, O.M. Karaman, L.M. Yevstratieva, I.M. Voyeykova, H.P. Potebnia // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 42-48. — Бібліогр.: 27 назв. — англ.
series Experimental Oncology
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AT fedosovani anticancereffectandimmunologicresponsetoxenogeneicembryonicproteinsinmicebearingehrlichsolidcarcinoma
AT karamanom anticancereffectandimmunologicresponsetoxenogeneicembryonicproteinsinmicebearingehrlichsolidcarcinoma
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AT potebniahp anticancereffectandimmunologicresponsetoxenogeneicembryonicproteinsinmicebearingehrlichsolidcarcinoma
first_indexed 2023-10-18T21:16:09Z
last_indexed 2023-10-18T21:16:09Z
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