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Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability
Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the d...
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Series: | Experimental Oncology |
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| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/137633 |
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irk-123456789-1376332018-06-18T03:10:36Z Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability Krasnopolsky, Y.M. Dudnichenko, A.S. Original contributions Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the docetaxel incorporation has been considered. Results: Reduction of toxicity of the liposomal form of docetaxel (LD₅₀ — 137 ± 7.7 mg/kg) was found in comparison with its free form (LD₅₀ — 101 ± 6.3 mg/kg). Preservation of nanosize particle after lyophilization has been shown. Conclusions: As a result of the studies, the optimal composition and technological scheme for obtaining liposomes containing docetaxel have been developed allowing large-scale production of docetaxel in liposomal form. 2017 Article Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability / Y.M. Krasnopolsky, А.S. Dudnichenko // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 121-123. — Бібліогр.: 22 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137633 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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English |
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Original contributions Original contributions |
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Original contributions Original contributions Krasnopolsky, Y.M. Dudnichenko, A.S. Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability Experimental Oncology |
| description |
Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the docetaxel incorporation has been considered. Results: Reduction of toxicity of the liposomal form of docetaxel (LD₅₀ — 137 ± 7.7 mg/kg) was found in comparison with its free form (LD₅₀ — 101 ± 6.3 mg/kg). Preservation of nanosize particle after lyophilization has been shown. Conclusions: As a result of the studies, the optimal composition and technological scheme for obtaining liposomes containing docetaxel have been developed allowing large-scale production of docetaxel in liposomal form. |
| format |
Article |
| author |
Krasnopolsky, Y.M. Dudnichenko, A.S. |
| author_facet |
Krasnopolsky, Y.M. Dudnichenko, A.S. |
| author_sort |
Krasnopolsky, Y.M. |
| title |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_short |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_full |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_fullStr |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_full_unstemmed |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_sort |
experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2017 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137633 |
| citation_txt |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability / Y.M. Krasnopolsky, А.S. Dudnichenko // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 121-123. — Бібліогр.: 22 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT krasnopolskyym experimentalstudyofliposomaldocetaxelanalysisofdocetaxelincorporationandstability AT dudnichenkoas experimentalstudyofliposomaldocetaxelanalysisofdocetaxelincorporationandstability |
| first_indexed |
2023-10-18T21:16:24Z |
| last_indexed |
2023-10-18T21:16:24Z |
| _version_ |
1796152381643161600 |