Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness

Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness

Aim: To assess radioprotective activity of astaxanthin toward radiation-induced in vitro cytogenetic effects in human peripheral blood lymphocytes (PBL). Materials and Methods: PBL from the cleanup workers exposed to ionizing radiation at high doses in 1986 during accident on Chornobyl nuclear power...

Повний опис

Збережено в:
Бібліографічні деталі
Дата:2016
Автори: Kurinnyi, D.A., Rushkovsky, S.R., Dybska, O.B., Dubrovina, G.V., Pilinska, M.A.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
Назва видання:Experimental Oncology
Теми:
Short communications
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/137688
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness / D.А. Кurinnyi, S.R. Rushkovsky, О.B. Dybska, G.V. Dubrovina, M.А. Pilinska // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 280-282. — Бібліогр.: 9 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-137688
record_format dspace
spelling irk-123456789-1376882020-12-08T14:51:27Z Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness Kurinnyi, D.A. Rushkovsky, S.R. Dybska, O.B. Dubrovina, G.V. Pilinska, M.A. Short communications Aim: To assess radioprotective activity of astaxanthin toward radiation-induced in vitro cytogenetic effects in human peripheral blood lymphocytes (PBL). Materials and Methods: PBL from the cleanup workers exposed to ionizing radiation at high doses in 1986 during accident on Chornobyl nuclear power plant and who were diagnosed with acute radiation sickness of the first and second degrees, were cultured in vitro. Astaxanthin was added into the culture medium at a final concentration of 20.0 µg/ml, prior to γ-irradiation of PBL in vitro at a dose of 1 Gy. The slides of metaphase chromosomes were analyzed. Results: Astaxanthin demonstrated considerable radioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cyto radioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cytoradioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cytogenetic markers of radiation exposure (dicentrics and centric rings). Conclusion: The data evidence on radioprotective capacity of astaxanthin toward radiation-induced cytogenetic effects in vitro in PBL of liquidators irradiated during Chornobyl nuclear power plant accident. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. 2016 Article Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness / D.А. Кurinnyi, S.R. Rushkovsky, О.B. Dybska, G.V. Dubrovina, M.А. Pilinska // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 280-282. — Бібліогр.: 9 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137688 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Kurinnyi, D.A.
Rushkovsky, S.R.
Dybska, O.B.
Dubrovina, G.V.
Pilinska, M.A.
Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
Experimental Oncology
description Aim: To assess radioprotective activity of astaxanthin toward radiation-induced in vitro cytogenetic effects in human peripheral blood lymphocytes (PBL). Materials and Methods: PBL from the cleanup workers exposed to ionizing radiation at high doses in 1986 during accident on Chornobyl nuclear power plant and who were diagnosed with acute radiation sickness of the first and second degrees, were cultured in vitro. Astaxanthin was added into the culture medium at a final concentration of 20.0 µg/ml, prior to γ-irradiation of PBL in vitro at a dose of 1 Gy. The slides of metaphase chromosomes were analyzed. Results: Astaxanthin demonstrated considerable radioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cyto radioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cytoradioprotective effect in irradiated PBL manifested in significantly decreased levels of unstable cytogenetic markers of radiation exposure (dicentrics and centric rings). Conclusion: The data evidence on radioprotective capacity of astaxanthin toward radiation-induced cytogenetic effects in vitro in PBL of liquidators irradiated during Chornobyl nuclear power plant accident. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
format Article
author Kurinnyi, D.A.
Rushkovsky, S.R.
Dybska, O.B.
Dubrovina, G.V.
Pilinska, M.A.
author_facet Kurinnyi, D.A.
Rushkovsky, S.R.
Dybska, O.B.
Dubrovina, G.V.
Pilinska, M.A.
author_sort Kurinnyi, D.A.
title Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
title_short Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
title_full Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
title_fullStr Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
title_full_unstemmed Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
title_sort astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2016
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/137688
citation_txt Astaxanthin modifies clastogenic effects of ionizing radiation in vitro in peripheral blood lymphocytes of the persons recovered from acute radiation sickness / D.А. Кurinnyi, S.R. Rushkovsky, О.B. Dybska, G.V. Dubrovina, M.А. Pilinska // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 280-282. — Бібліогр.: 9 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT kurinnyida astaxanthinmodifiesclastogeniceffectsofionizingradiationinvitroinperipheralbloodlymphocytesofthepersonsrecoveredfromacuteradiationsickness
AT rushkovskysr astaxanthinmodifiesclastogeniceffectsofionizingradiationinvitroinperipheralbloodlymphocytesofthepersonsrecoveredfromacuteradiationsickness
AT dybskaob astaxanthinmodifiesclastogeniceffectsofionizingradiationinvitroinperipheralbloodlymphocytesofthepersonsrecoveredfromacuteradiationsickness
AT dubrovinagv astaxanthinmodifiesclastogeniceffectsofionizingradiationinvitroinperipheralbloodlymphocytesofthepersonsrecoveredfromacuteradiationsickness
AT pilinskama astaxanthinmodifiesclastogeniceffectsofionizingradiationinvitroinperipheralbloodlymphocytesofthepersonsrecoveredfromacuteradiationsickness
first_indexed 2023-10-18T21:16:11Z
last_indexed 2023-10-18T21:16:11Z
_version_ 1796152366824685568

Схожі ресурси