Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident

Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident

In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiati...

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Збережено в:
Бібліографічні деталі
Дата:2016
Автори: Pilinska, M.A., Shemetun, G.M., Shemetun, O.V., Dybsky, S.S., Dybska, O.B., Talan, O.O., Pedan, L.R., Kurinnyi, D.A.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
Назва видання:Experimental Oncology
Теми:
Lectures
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/137692
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident / M.A. Pilinska, G.M. Shemetun , O.V. Shemetun, S.S. Dybsky , O.B. Dybska, O.O. Talan, L.R. Pedan, D.А. Kurinnyi // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 276-279. — Бібліогр.: 21 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-137692
record_format dspace
spelling irk-123456789-1376922020-12-08T14:52:36Z Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident Pilinska, M.A. Shemetun, G.M. Shemetun, O.V. Dybsky, S.S. Dybska, O.B. Talan, O.O. Pedan, L.R. Kurinnyi, D.A. Lectures In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiation after Chornobyl accident in Ukraine. It is highlighted that not only targeted but also untargeted radiation-induced cytogenetic effects should be explored, especially in delayed terms following radiation exposure. The new methodical approaches for studying “bystander effect”, individual radiosensitivity, and various forms of radiation-induced chromosomal instability (delayed, hidden, transmissible) have been proposed. These approaches proved to be advantageous for analyzing cytogenetic patterns of induction and persistence of chromosomal instability in human somatic cells because of “bystander effect” and “bystander type effect”. The phenomenon of positive “reverse” bystander effect has been found. The possibility of modifying the inherited individual human susceptibility to mutagenic exposure by ionizing radiation has been estimated. Finally, the association between hypersensitivity to radiation exposure and realization of oncopathology in exposed individuals has been revealed. The increased intensity of human somatic chromosomal mutagenesis was confirmed not only in the nearest but in the delayed terms following Chornobyl accident as a result of radiation-induced both targeted and untargeted cytogenetic effects. Such effects can be considered as risk factors for malignant transformation of cells, hereditary diseases, birth defects, and multifactorial somatic pathology. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. 2016 Article Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident / M.A. Pilinska, G.M. Shemetun , O.V. Shemetun, S.S. Dybsky , O.B. Dybska, O.O. Talan, L.R. Pedan, D.А. Kurinnyi // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 276-279. — Бібліогр.: 21 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137692 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Lectures
Lectures
spellingShingle Lectures
Lectures
Pilinska, M.A.
Shemetun, G.M.
Shemetun, O.V.
Dybsky, S.S.
Dybska, O.B.
Talan, O.O.
Pedan, L.R.
Kurinnyi, D.A.
Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
Experimental Oncology
description In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiation after Chornobyl accident in Ukraine. It is highlighted that not only targeted but also untargeted radiation-induced cytogenetic effects should be explored, especially in delayed terms following radiation exposure. The new methodical approaches for studying “bystander effect”, individual radiosensitivity, and various forms of radiation-induced chromosomal instability (delayed, hidden, transmissible) have been proposed. These approaches proved to be advantageous for analyzing cytogenetic patterns of induction and persistence of chromosomal instability in human somatic cells because of “bystander effect” and “bystander type effect”. The phenomenon of positive “reverse” bystander effect has been found. The possibility of modifying the inherited individual human susceptibility to mutagenic exposure by ionizing radiation has been estimated. Finally, the association between hypersensitivity to radiation exposure and realization of oncopathology in exposed individuals has been revealed. The increased intensity of human somatic chromosomal mutagenesis was confirmed not only in the nearest but in the delayed terms following Chornobyl accident as a result of radiation-induced both targeted and untargeted cytogenetic effects. Such effects can be considered as risk factors for malignant transformation of cells, hereditary diseases, birth defects, and multifactorial somatic pathology. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
format Article
author Pilinska, M.A.
Shemetun, G.M.
Shemetun, O.V.
Dybsky, S.S.
Dybska, O.B.
Talan, O.O.
Pedan, L.R.
Kurinnyi, D.A.
author_facet Pilinska, M.A.
Shemetun, G.M.
Shemetun, O.V.
Dybsky, S.S.
Dybska, O.B.
Talan, O.O.
Pedan, L.R.
Kurinnyi, D.A.
author_sort Pilinska, M.A.
title Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
title_short Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
title_full Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
title_fullStr Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
title_full_unstemmed Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
title_sort chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2016
topic_facet Lectures
url http://dspace.nbuv.gov.ua/handle/123456789/137692
citation_txt Chromosomal mutagenesis in human somatic cells: 30-year cytogenetic monitoring after chornobyl accident / M.A. Pilinska, G.M. Shemetun , O.V. Shemetun, S.S. Dybsky , O.B. Dybska, O.O. Talan, L.R. Pedan, D.А. Kurinnyi // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 276-279. — Бібліогр.: 21 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:16:11Z
last_indexed 2023-10-18T21:16:11Z
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