Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident

Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident

Aim: To study the genetic effects in children exposed to radiation in utero as a result of the Chornobyl nuclear power plant accident accounting the total radiation doses and equivalent radiation doses to the red bone marrow. Materials and Methods: Incidence of minor developmental anomalies was stud...

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Видавець:Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Дата:2016
Автори: Stepanova, Ye.I., Vdovenko, V.Yu., Misharina, Zh.A., Kolos, V.I., Mischenko, L.P.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/137712
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Цитувати:Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident / Ye.I. Stepanova, V.Yu. Vdovenko, Zh.A. Misharina, V.I. Kolos, L.P. Mischenko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 272-275. — Бібліогр.: 23 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1377122018-06-18T03:06:34Z Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident Stepanova, Ye.I. Vdovenko, V.Yu. Misharina, Zh.A. Kolos, V.I. Mischenko, L.P. Original contributions Aim: To study the genetic effects in children exposed to radiation in utero as a result of the Chornobyl nuclear power plant accident accounting the total radiation doses and equivalent radiation doses to the red bone marrow. Materials and Methods: Incidence of minor developmental anomalies was studied in children exposed to radiation in utero (study group) and in the control group (1144 subjects surveyed in total). Cytogenetic tests using the method of differential G-banding of chromosomes were conducted in 60 children of both study and control groups (10–12-year-olds) and repeatedly in 39 adolescents (15–17-year-olds). Results: A direct correlation was found between the number of minor developmental anomalies and fetal dose of radiation, and a reverse one with fetal gestational age at the time of radiation exposure. Incidence of chromosomal damage in somatic cells of 10–12-year-old children exposed prenatally was associated with radiation dose to the red bone marrow. The repeated testing has revealed that an increased level of chromosomal aberrations was preserved in a third of adolescents. Conclusion: The persons exposed to ionizing radiation at prenatal period should be attributed to the group of carcinogenic risk due to persisting increased levels of chromosome damage. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. 2016 Article Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident / Ye.I. Stepanova, V.Yu. Vdovenko, Zh.A. Misharina, V.I. Kolos, L.P. Mischenko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 272-275. — Бібліогр.: 23 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137712 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Stepanova, Ye.I.
Vdovenko, V.Yu.
Misharina, Zh.A.
Kolos, V.I.
Mischenko, L.P.
Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
Experimental Oncology
description Aim: To study the genetic effects in children exposed to radiation in utero as a result of the Chornobyl nuclear power plant accident accounting the total radiation doses and equivalent radiation doses to the red bone marrow. Materials and Methods: Incidence of minor developmental anomalies was studied in children exposed to radiation in utero (study group) and in the control group (1144 subjects surveyed in total). Cytogenetic tests using the method of differential G-banding of chromosomes were conducted in 60 children of both study and control groups (10–12-year-olds) and repeatedly in 39 adolescents (15–17-year-olds). Results: A direct correlation was found between the number of minor developmental anomalies and fetal dose of radiation, and a reverse one with fetal gestational age at the time of radiation exposure. Incidence of chromosomal damage in somatic cells of 10–12-year-old children exposed prenatally was associated with radiation dose to the red bone marrow. The repeated testing has revealed that an increased level of chromosomal aberrations was preserved in a third of adolescents. Conclusion: The persons exposed to ionizing radiation at prenatal period should be attributed to the group of carcinogenic risk due to persisting increased levels of chromosome damage. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
format Article
author Stepanova, Ye.I.
Vdovenko, V.Yu.
Misharina, Zh.A.
Kolos, V.I.
Mischenko, L.P.
author_facet Stepanova, Ye.I.
Vdovenko, V.Yu.
Misharina, Zh.A.
Kolos, V.I.
Mischenko, L.P.
author_sort Stepanova, Ye.I.
title Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
title_short Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
title_full Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
title_fullStr Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
title_full_unstemmed Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
title_sort genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2016
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/137712
citation_txt Genetic effects in children exposed in prenatal period to ionizing radiation after the chornobyl nuclear power plant accident / Ye.I. Stepanova, V.Yu. Vdovenko, Zh.A. Misharina, V.I. Kolos, L.P. Mischenko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 272-275. — Бібліогр.: 23 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:16:13Z
last_indexed 2023-10-18T21:16:13Z
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