Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease

Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease

Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study...

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Дата:2016
Автори: Naleskina, L.A., Lukianova, N.Yu., Sobchenko, S.O., Storchai, D.M., Chekhun, V.F.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/137731
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1377312018-06-18T03:05:29Z Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease Naleskina, L.A. Lukianova, N.Yu. Sobchenko, S.O. Storchai, D.M. Chekhun, V.F. Original contributions Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study, and 151 BC patients — prospective study) were analyzed. Morphological, immunohistochemical and statistical methods were used. Results: The number of LF-positive tumors in retrospective and prospective groups was similar (52.1 and 52.8%, respectively). Among common clinical criteria for prognosis of the disease outcome in BC patients (patient’s age; stage of the disease; histological type, differentiation grade, receptor status; presence of metastases), a strong correlation was found only between expression indexes of LF and estrogen receptors (ER). In ER-positive tumors expression of LF was significantly higher than in ER-negative tumors (35 vs 18%). 5-Year survival rate of BC patients was higher in LF-positive group (70 vs 52% in LF-negative group). The presence of regional metastasis tended to correlate with an increased number of LF-positive tumors. In the patients with invasive ductal carcinoma, expression level of LF moderately correlated with occurrence of luminal A subtype (r = 0.43), while in the patients with invasive lobular carcinoma this index strongly correlated with occurrence of luminal B subtype (r = 0.71). LF expression correlated positively with low and moderate differentiation grade of luminal B or basal tumors, and negatively with luminal B or basal tumors of high differentiation grade (r = −0.57 and −0.63, respectively). Conclusion: It has been shown that LF expression in breast tumors correlated with life expectancy of BC patients and important physiologic and clinical features of the disease, while the character of such relation strongly depended on molecular phenotype of tumor, i.e. luminal A, luminal B or basal. 2016 Article Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137731 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
Experimental Oncology
description Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study, and 151 BC patients — prospective study) were analyzed. Morphological, immunohistochemical and statistical methods were used. Results: The number of LF-positive tumors in retrospective and prospective groups was similar (52.1 and 52.8%, respectively). Among common clinical criteria for prognosis of the disease outcome in BC patients (patient’s age; stage of the disease; histological type, differentiation grade, receptor status; presence of metastases), a strong correlation was found only between expression indexes of LF and estrogen receptors (ER). In ER-positive tumors expression of LF was significantly higher than in ER-negative tumors (35 vs 18%). 5-Year survival rate of BC patients was higher in LF-positive group (70 vs 52% in LF-negative group). The presence of regional metastasis tended to correlate with an increased number of LF-positive tumors. In the patients with invasive ductal carcinoma, expression level of LF moderately correlated with occurrence of luminal A subtype (r = 0.43), while in the patients with invasive lobular carcinoma this index strongly correlated with occurrence of luminal B subtype (r = 0.71). LF expression correlated positively with low and moderate differentiation grade of luminal B or basal tumors, and negatively with luminal B or basal tumors of high differentiation grade (r = −0.57 and −0.63, respectively). Conclusion: It has been shown that LF expression in breast tumors correlated with life expectancy of BC patients and important physiologic and clinical features of the disease, while the character of such relation strongly depended on molecular phenotype of tumor, i.e. luminal A, luminal B or basal.
format Article
author Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
author_facet Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
author_sort Naleskina, L.A.
title Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_short Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_full Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_fullStr Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_full_unstemmed Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_sort lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2016
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/137731
citation_txt Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ.
series Experimental Oncology
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AT sobchenkoso lactoferrinexpressioninbreastcancerinrelationtobiologicpropertiesoftumorsandclinicalfeaturesofdisease
AT storchaidm lactoferrinexpressioninbreastcancerinrelationtobiologicpropertiesoftumorsandclinicalfeaturesofdisease
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first_indexed 2023-10-18T21:14:48Z
last_indexed 2023-10-18T21:14:48Z
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