Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity

Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity

Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor...

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Бібліографічні деталі
Дата:2016
Автори: Shevchuk, O.O., Bodnar, Ya.Ya., Bardakhivska, K.I., Datsko, T.V., Volska, A.S., Posokhova, K.A., Chekhun, V.F., Nikolaev, V.G.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/137734
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1377342018-06-18T03:05:35Z Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity Shevchuk, O.O. Bodnar, Ya.Ya. Bardakhivska, K.I. Datsko, T.V. Volska, A.S. Posokhova, K.A. Chekhun, V.F. Nikolaev, V.G. Original contributions Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology. The aim of our investigation was to study the efficiency of combined use of enterosorption and G-CSF to decrease gonadal toxicity of chemotherapy. Materials and Methods: Melphalan (L-PAM) injected i.v. at a single dose of 4 mg/kg to white inbred rats was used as gonadotoxic and myelosuppressing agent. Carbon enterosorbent C2 was administered by intragastric route as a suspension in saline at a dose of 5 ml per 1 kg of rats’ body weight (or 900 mg/kg of the dry mass of enterosorbent) daily for 3 days before and for 7 days after L-PAM injection. G-CSF was injected once a day for 4 days starting from the next day after L-PAM administration at a dose of 50 µg/kg. Histological preparations of testicular tissues were examined by light microscopy. Results: Our findings have shown that melphalan caused marked damage of testicular tissues and seminiferous, especially spermatogenic epithelium. The most expressed protection of the histological structure of testes was observed when enterosorbent and G-CSF were used in combination. Conclusion: Gonadal toxicity of chemotherapy could be efficiently decreased by the combined use of enterosorption and G-CSF. 2016 Article Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137734 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Shevchuk, O.O.
Bodnar, Ya.Ya.
Bardakhivska, K.I.
Datsko, T.V.
Volska, A.S.
Posokhova, K.A.
Chekhun, V.F.
Nikolaev, V.G.
Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
Experimental Oncology
description Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology. The aim of our investigation was to study the efficiency of combined use of enterosorption and G-CSF to decrease gonadal toxicity of chemotherapy. Materials and Methods: Melphalan (L-PAM) injected i.v. at a single dose of 4 mg/kg to white inbred rats was used as gonadotoxic and myelosuppressing agent. Carbon enterosorbent C2 was administered by intragastric route as a suspension in saline at a dose of 5 ml per 1 kg of rats’ body weight (or 900 mg/kg of the dry mass of enterosorbent) daily for 3 days before and for 7 days after L-PAM injection. G-CSF was injected once a day for 4 days starting from the next day after L-PAM administration at a dose of 50 µg/kg. Histological preparations of testicular tissues were examined by light microscopy. Results: Our findings have shown that melphalan caused marked damage of testicular tissues and seminiferous, especially spermatogenic epithelium. The most expressed protection of the histological structure of testes was observed when enterosorbent and G-CSF were used in combination. Conclusion: Gonadal toxicity of chemotherapy could be efficiently decreased by the combined use of enterosorption and G-CSF.
format Article
author Shevchuk, O.O.
Bodnar, Ya.Ya.
Bardakhivska, K.I.
Datsko, T.V.
Volska, A.S.
Posokhova, K.A.
Chekhun, V.F.
Nikolaev, V.G.
author_facet Shevchuk, O.O.
Bodnar, Ya.Ya.
Bardakhivska, K.I.
Datsko, T.V.
Volska, A.S.
Posokhova, K.A.
Chekhun, V.F.
Nikolaev, V.G.
author_sort Shevchuk, O.O.
title Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
title_short Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
title_full Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
title_fullStr Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
title_full_unstemmed Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
title_sort enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2016
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/137734
citation_txt Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:14:48Z
last_indexed 2023-10-18T21:14:48Z
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