The role of cadherin/catenin complex in malignant melanoma
In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer inv...
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| Дата: | 2006 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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| Назва видання: | Experimental Oncology |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/137921 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The role of cadherin/catenin complex in malignant melanoma / N. Bonitsis, A. Batistatou, S. Karantima, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 187-193. — Бібліогр.: 78 назв. — англ. |
Репозитарії
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irk-123456789-1379212018-06-18T03:04:52Z The role of cadherin/catenin complex in malignant melanoma Bonitsis, N. Batistatou, A. Karantima, S. Charalabopoulos, K. In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief. В обзоре обсуждается роль кадгерин/катенинового комплекса при злокачественной меланоме. Кадгерины представляют собой суперсемейство адгезивных молекул, среди которых наиболее изучен эпителиальный кадгерин (E-кадгерин), выполняющий ключевую роль в норме и при инвазивном опухолевом росте и метастазировании. В ткани злокачественных меланом уровень экспрессии E-кадгерина изменен, его снижение или отсутствие связано с инвазивным ростом и метастазированием опухоли. При образовании злокачественных меланом в меланоцитах отмечают замену экспрессии E-кадерина на таковую неврального кадгерина (N-кадгерина). Кроме того, коротко обсуждается роль плацентарного кадгерина (P-кадгерина), эндотелиального кадгерина сосудов (VE-кадерина) и недавно идентифицированного дисадгерина. 2006 Article The role of cadherin/catenin complex in malignant melanoma / N. Bonitsis, A. Batistatou, S. Karantima, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 187-193. — Бібліогр.: 78 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137921 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| description |
In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief. |
| format |
Article |
| author |
Bonitsis, N. Batistatou, A. Karantima, S. Charalabopoulos, K. |
| spellingShingle |
Bonitsis, N. Batistatou, A. Karantima, S. Charalabopoulos, K. The role of cadherin/catenin complex in malignant melanoma Experimental Oncology |
| author_facet |
Bonitsis, N. Batistatou, A. Karantima, S. Charalabopoulos, K. |
| author_sort |
Bonitsis, N. |
| title |
The role of cadherin/catenin complex in malignant melanoma |
| title_short |
The role of cadherin/catenin complex in malignant melanoma |
| title_full |
The role of cadherin/catenin complex in malignant melanoma |
| title_fullStr |
The role of cadherin/catenin complex in malignant melanoma |
| title_full_unstemmed |
The role of cadherin/catenin complex in malignant melanoma |
| title_sort |
role of cadherin/catenin complex in malignant melanoma |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137921 |
| citation_txt |
The role of cadherin/catenin complex in malignant melanoma / N. Bonitsis, A. Batistatou,
S. Karantima, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 187-193. — Бібліогр.: 78 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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| first_indexed |
2023-10-18T21:14:33Z |
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2023-10-18T21:14:33Z |
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