A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice
Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness...
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| Дата: | 2016 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/137980 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. |
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irk-123456789-1379802018-06-18T03:02:47Z A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. Short communications Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness of a nutrient mixture (NM) containing ascorbic acid, lysine, proline, and green tea extract in vitro: on activity of urokinase plasminogen activator, matrix metalloproteinases and TIMPs in various human glioblastoma (LN-18, T-98G and A-172) cell lines and on glioblastoma A-172 cell proliferation and Matrigel invasion. Aim: Our main objective in this study was to investigate the effect of the NM in vivo on human glioblastoma U-87 MG cell line. Materials and Methods: Athymic male nude mice inoculated with 3·106 U-87 MG cells subcutaneously and were fed a regular diet or a regular diet supplemented with 0.5% NM. Four weeks later, the mice were sacrificed, the tumors were weighed and measured. The samples were studied histologically. Results: NM inhibited tumor weight and tumor burden by 53% (p = 0.015) and 48% (p = 0.010), respectively. Conclusions: These results suggest the therapeutic potential of NM as an adjuvant in the treatment of glioblastoma. 2016 Article A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137980 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice Experimental Oncology |
| description |
Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness of a nutrient mixture (NM) containing ascorbic acid, lysine, proline, and green tea extract in vitro: on activity of urokinase plasminogen activator, matrix metalloproteinases and TIMPs in various human glioblastoma (LN-18, T-98G and A-172) cell lines and on glioblastoma A-172 cell proliferation and Matrigel invasion. Aim: Our main objective in this study was to investigate the effect of the NM in vivo on human glioblastoma U-87 MG cell line. Materials and Methods: Athymic male nude mice inoculated with 3·106 U-87 MG cells subcutaneously and were fed a regular diet or a regular diet supplemented with 0.5% NM. Four weeks later, the mice were sacrificed, the tumors were weighed and measured. The samples were studied histologically. Results: NM inhibited tumor weight and tumor burden by 53% (p = 0.015) and 48% (p = 0.010), respectively. Conclusions: These results suggest the therapeutic potential of NM as an adjuvant in the treatment of glioblastoma. |
| format |
Article |
| author |
Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. |
| author_facet |
Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. |
| author_sort |
Roomi, M.W. |
| title |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_short |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_full |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_fullStr |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_full_unstemmed |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_sort |
nutrient mixture inhibits glioblastoma xenograft u-87 mg growth in male nude mice |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2016 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137980 |
| citation_txt |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:14:20Z |
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2023-10-18T21:14:20Z |
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