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Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival

Aim: This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients. Methods: Seventy-five paraffinembedded primary tumors were stain...

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Main Authors: Goncharuk, I.V., Vorobjova, L.I., Lukyanova, N.Yu., Chekhun, V.F.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Series:Experimental Oncology
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Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138134
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spelling irk-123456789-1381342018-06-19T03:02:59Z Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival Goncharuk, I.V. Vorobjova, L.I. Lukyanova, N.Yu. Chekhun, V.F. Short communications Aim: This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients. Methods: Seventy-five paraffinembedded primary tumors were stained immunohistochemically for VEGF expression, which was analysed semiquantitatively. Results: The significant correlation between VEGF expression and stages of disease, as well as pelvic lymph node metastasis was observed. There were determined a negative correlations between VEGF expression in tumor cells and both overall and disease-free survival. Conclusion: VEGF expression in human cervical cancer may be used as a diagnostic parameter in the clinic. Our results are in accordance with literature data showing association of VEGF overexpression in tumor with a poorer patient survival. 2009 Article Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival / I.V. Goncharuk, L.I. Vorobjova, N.Yu. Lukyanova, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 179-181. — Бібліогр.: 24 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138134 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Goncharuk, I.V.
Vorobjova, L.I.
Lukyanova, N.Yu.
Chekhun, V.F.
Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
Experimental Oncology
description Aim: This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients. Methods: Seventy-five paraffinembedded primary tumors were stained immunohistochemically for VEGF expression, which was analysed semiquantitatively. Results: The significant correlation between VEGF expression and stages of disease, as well as pelvic lymph node metastasis was observed. There were determined a negative correlations between VEGF expression in tumor cells and both overall and disease-free survival. Conclusion: VEGF expression in human cervical cancer may be used as a diagnostic parameter in the clinic. Our results are in accordance with literature data showing association of VEGF overexpression in tumor with a poorer patient survival.
format Article
author Goncharuk, I.V.
Vorobjova, L.I.
Lukyanova, N.Yu.
Chekhun, V.F.
author_facet Goncharuk, I.V.
Vorobjova, L.I.
Lukyanova, N.Yu.
Chekhun, V.F.
author_sort Goncharuk, I.V.
title Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
title_short Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
title_full Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
title_fullStr Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
title_full_unstemmed Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
title_sort vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/138134
citation_txt Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival / I.V. Goncharuk, L.I. Vorobjova, N.Yu. Lukyanova, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 179-181. — Бібліогр.: 24 назв. — англ.
series Experimental Oncology
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AT lukyanovanyu vascularendothelialgrowthfactorexressioninuterinecervicalcancercorrelationwithclinicopathologiccharacteristicsandsurvival
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first_indexed 2023-10-18T21:17:31Z
last_indexed 2023-10-18T21:17:31Z
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