Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma
To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metas...
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| Дата: | 2009 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138140 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1381402018-06-19T03:03:08Z Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. Original contributions To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metastases were measured as the indices of ATV efficacy. The activity of cytotoxic T-lymphocytes and natural killer cells, peritoneal macrophages (Mph), the level of tumor necrosis factor and the total proteolytic activity of blood plasma (PA) were assessed. Results: ATV from CP resistant LLC prepared using cytolectin (CL) of В. subtilis В-7025 significantly inhibited growth of CP resistant tumors (by 52%) and increased mean survival time (MST) of animals (by 44.6%). The index of metastasis inhibition for ATV prepared from CP sensitive or resistant LLC was 154.5% and 227.0%, respectively. In all vaccine-treated animals, Mph activity was shown to be significantly increased. In spite of high antitumor and antimetastatic effects of ATV prepared from CP resistant LLC, PA in plasma of animals inoculated with CP resistant LLC was increased significantly upon vaccine administration. 2009 Article Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138140 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma Experimental Oncology |
| description |
To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metastases were measured as the indices of ATV efficacy. The activity of cytotoxic T-lymphocytes and natural killer cells, peritoneal macrophages (Mph), the level of tumor necrosis factor and the total proteolytic activity of blood plasma (PA) were assessed. Results: ATV from CP resistant LLC prepared using cytolectin (CL) of В. subtilis В-7025 significantly inhibited growth of CP resistant tumors (by 52%) and increased mean survival time (MST) of animals (by 44.6%). The index of metastasis inhibition for ATV prepared from CP sensitive or resistant LLC was 154.5% and 227.0%, respectively. In all vaccine-treated animals, Mph activity was shown to be significantly increased. In spite of high antitumor and antimetastatic effects of ATV prepared from CP resistant LLC, PA in plasma of animals inoculated with CP resistant LLC was increased significantly upon vaccine administration. |
| format |
Article |
| author |
Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. |
| author_facet |
Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. |
| author_sort |
Potebnya, G.P. |
| title |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_short |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_full |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_fullStr |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_full_unstemmed |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_sort |
antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2009 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138140 |
| citation_txt |
Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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2023-10-18T21:17:32Z |
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2023-10-18T21:17:32Z |
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