Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action

Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action

Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with aut...

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Дата:2009
Автори: Berezhnaya, N.M., Belova, O.B., Vinnichuk, Yu.D., Tarutinov, V.I.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138143
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1381432018-06-19T03:03:00Z Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action Berezhnaya, N.M. Belova, O.B. Vinnichuk, Yu.D. Tarutinov, V.I. Original contributions Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with autologous lymphocytes in double diffusion chambers. The results were evaluated by morphological criteria of explants growth. Expression level of proteins on tumor cells was analyzed using immunohistochemical method on paraffin embedded sections, and by indirect immunofluorescence — on lymphocytes. Results: Significant decrease of E-cadherin expression and significant increase of nuclear antigen of proliferating cells expression have been detected on drug resistant malignant human breast tumor (DRHBT) cells compared with drug sensitive breast tumor (DSHBT) cells. Autologous LAK possessed the highest antitumor activity against DRHBT cells that was associated with high expression level of soybean lectin receptor. Conclusion: Malignant drug resistant tumors are characterized by reverse relation between E-cadherin expression level and their proliferative activity. Marked antitumor action of LAK against these tumors is associated with high expression level of soybean lectin receptor on the lymphocytes. 2009 Article Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138143 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
Experimental Oncology
description Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with autologous lymphocytes in double diffusion chambers. The results were evaluated by morphological criteria of explants growth. Expression level of proteins on tumor cells was analyzed using immunohistochemical method on paraffin embedded sections, and by indirect immunofluorescence — on lymphocytes. Results: Significant decrease of E-cadherin expression and significant increase of nuclear antigen of proliferating cells expression have been detected on drug resistant malignant human breast tumor (DRHBT) cells compared with drug sensitive breast tumor (DSHBT) cells. Autologous LAK possessed the highest antitumor activity against DRHBT cells that was associated with high expression level of soybean lectin receptor. Conclusion: Malignant drug resistant tumors are characterized by reverse relation between E-cadherin expression level and their proliferative activity. Marked antitumor action of LAK against these tumors is associated with high expression level of soybean lectin receptor on the lymphocytes.
format Article
author Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
author_facet Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
author_sort Berezhnaya, N.M.
title Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_short Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_full Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_fullStr Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_full_unstemmed Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_sort expression of e-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2009
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138143
citation_txt Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ.
series Experimental Oncology
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AT vinnichukyud expressionofecadherinindrugresistanthumanbreastcancercellsandtheirsensitivitytolymphokineactivatedlymphocytesaction
AT tarutinovvi expressionofecadherinindrugresistanthumanbreastcancercellsandtheirsensitivitytolymphokineactivatedlymphocytesaction
first_indexed 2023-10-18T21:17:32Z
last_indexed 2023-10-18T21:17:32Z
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