Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells
Aim: To study the effect of fullerene-containing composites, irradiated by visible light, on the radical oxygen species (ROS) generation in thymocytes, ascitic cells from Erlich’s tumor and leukemia cells L1210; to investigate viability of these cells in the presence of fullerene-containing composit...
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| Дата: | 2006 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138177 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells / U. Ritter, P. Scharff, S.V. Prylutska, O.P. Matyshevska, A.P. Burlaka, A.А. Golub, G.P. Potebnya br, Y.I. Prylutskyy // Experimental Oncology. — 2006. — Т. 28, № 2. — С. 160-162. — Бібліогр.: 11 назв. — англ. |
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irk-123456789-1381772018-06-19T03:02:57Z Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells Ritter, U. Scharff, P. Prylutska, S.V. Matyshevska, O.P. Burlaka, A.P. Golub, A.А. Potebnya br, G.P. Prylutskyy, Y.I. Short communications Aim: To study the effect of fullerene-containing composites, irradiated by visible light, on the radical oxygen species (ROS) generation in thymocytes, ascitic cells from Erlich’s tumor and leukemia cells L1210; to investigate viability of these cells in the presence of fullerene-containing composites under irradiation conditions. Materials and Methods: The viability of cells was evaluated by staining with 0.4% solution of the trypan blue; ROS were detected with the use of electron paramagnetic resonance (EPR) spectroscopy and spin traps; solutions of fullerene-containing composites were irradiated with mercury-vapor lamp. Results: We demonstrated that under irradiation conditions fullerene-containing composites increase the rate of ROS generation and decrease the number of viable tumor cells. Conclusions: The obtained data allow to consider the fullerene-containing composites as potential agents for photodynamic therapy. Цель: изучить влияние фуллеренсодержащих композитов, облученных видимым светом, на генерирование радикальных форм кислорода (РФК) в клетках тимоцитов, асцитного рака Эрлиха и лейкоза L1210. Исследовать жизнеспособность этих клеток в присутствии облученных фуллеренсодержащих композитов. Методы: жизнеспособность клеток определяли с использованием 0,4 % раствора трипанового синего; РФК регистрировали методом ЭПР- спектроскопии и спиновых ловушек; облучение водных раcтворов фуллеренсодержащих композитов в видимом диапазоне осуществляли с помощью ртутной лампы. Результаты: показано, что фуллеренсодержащие композиты при облучении повышают скорость генерирования РФК и уменьшают количество жизнеспособных опухолевых клеток. Выводы: полученные результаты позволяют рассматривать фуллеренсодержащие композиты как потенциальные препараты для фотодинамической терапии. 2006 Article Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells / U. Ritter, P. Scharff, S.V. Prylutska, O.P. Matyshevska, A.P. Burlaka, A.А. Golub, G.P. Potebnya br, Y.I. Prylutskyy // Experimental Oncology. — 2006. — Т. 28, № 2. — С. 160-162. — Бібліогр.: 11 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138177 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Ritter, U. Scharff, P. Prylutska, S.V. Matyshevska, O.P. Burlaka, A.P. Golub, A.А. Potebnya br, G.P. Prylutskyy, Y.I. Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells Experimental Oncology |
| description |
Aim: To study the effect of fullerene-containing composites, irradiated by visible light, on the radical oxygen species (ROS) generation in thymocytes, ascitic cells from Erlich’s tumor and leukemia cells L1210; to investigate viability of these cells in the presence of fullerene-containing composites under irradiation conditions. Materials and Methods: The viability of cells was evaluated by staining with 0.4% solution of the trypan blue; ROS were detected with the use of electron paramagnetic resonance (EPR) spectroscopy and spin traps; solutions of fullerene-containing composites were irradiated with mercury-vapor lamp. Results: We demonstrated that under irradiation conditions fullerene-containing composites increase the rate of ROS generation and decrease the number of viable tumor cells. Conclusions: The obtained data allow to consider the fullerene-containing composites as potential agents for photodynamic therapy. |
| format |
Article |
| author |
Ritter, U. Scharff, P. Prylutska, S.V. Matyshevska, O.P. Burlaka, A.P. Golub, A.А. Potebnya br, G.P. Prylutskyy, Y.I. |
| author_facet |
Ritter, U. Scharff, P. Prylutska, S.V. Matyshevska, O.P. Burlaka, A.P. Golub, A.А. Potebnya br, G.P. Prylutskyy, Y.I. |
| author_sort |
Ritter, U. |
| title |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| title_short |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| title_full |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| title_fullStr |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| title_full_unstemmed |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| title_sort |
effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138177 |
| citation_txt |
Effect of the visible light irradiation of fullerene containing composites on the ros generation and the viability of tumor cells / U. Ritter, P. Scharff, S.V. Prylutska, O.P. Matyshevska,
A.P. Burlaka, A.А. Golub, G.P. Potebnya br, Y.I. Prylutskyy // Experimental Oncology. — 2006. — Т. 28, № 2. — С. 160-162. — Бібліогр.: 11 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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| first_indexed |
2023-10-18T21:14:21Z |
| last_indexed |
2023-10-18T21:14:21Z |
| _version_ |
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