Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type
Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. The aim of the study was to analyze the content of CD133⁺cells in different brain tumors by immunofluorescence assay and immunohistochemical metho...
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| Дата: | 2017 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138544 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type / N.I. Lisyaniy, D.N. Stanetskaya, A.N. Lisyaniy, L.N. Belskaya // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 219–223. — Бібліогр.: 26 назв. — англ. |
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irk-123456789-1385442018-06-20T03:04:25Z Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type Lisyaniy, N.I. Stanetskaya, D.N. Lisyaniy, A.N. Belskaya, L.N. Original contributions Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. The aim of the study was to analyze the content of CD133⁺cells in different brain tumors by immunofluorescence assay and immunohistochemical method. Materials and Methods: The samples of different brain tumors removed during neurosurgical operations were studied for CD133 expression. Results: Immunofluorescence assay of tumor imprints revealed CD133⁺cells in 40–85% of tumors regardless of histological type. In malignant tumors, the count of CD133⁺cells was higher than in benign tumors. Immunohistochemical method used for detection of CD133⁺cells was less sensitive than immunofluorescence technique. The number of CD133⁺cells may vary even in tumors of the same histological type. In 20–30% of malignant tumors (glioblastomas, medulloblastomas), the content of CD133⁺cells was very low or not detected at all. Conclusions: In tumors of the brain of different genesis and degree of anaplasia CD133⁺cells are found out. In malignant tumors (glioblastomas and medulloblastomas), CD133⁺cells are much more frequently detected than in benign brain tumors. The content of CD133⁺cells in brain tumors is highly variable being small and some malignant tumors, indicating low predictive and diagnostic value of cancer stem cell content in clinical practice. 2017 Article Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type / N.I. Lisyaniy, D.N. Stanetskaya, A.N. Lisyaniy, L.N. Belskaya // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 219–223. — Бібліогр.: 26 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138544 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Lisyaniy, N.I. Stanetskaya, D.N. Lisyaniy, A.N. Belskaya, L.N. Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type Experimental Oncology |
| description |
Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. The aim of the study was to analyze the content of CD133⁺cells in different brain tumors by immunofluorescence assay and immunohistochemical method. Materials and Methods: The samples of different brain tumors removed during neurosurgical operations were studied for CD133 expression. Results: Immunofluorescence assay of tumor imprints revealed CD133⁺cells in 40–85% of tumors regardless of histological type. In malignant tumors, the count of CD133⁺cells was higher than in benign tumors. Immunohistochemical method used for detection of CD133⁺cells was less sensitive than immunofluorescence technique. The number of CD133⁺cells may vary even in tumors of the same histological type. In 20–30% of malignant tumors (glioblastomas, medulloblastomas), the content of CD133⁺cells was very low or not detected at all. Conclusions: In tumors of the brain of different genesis and degree of anaplasia CD133⁺cells are found out. In malignant tumors (glioblastomas and medulloblastomas), CD133⁺cells are much more frequently detected than in benign brain tumors. The content of CD133⁺cells in brain tumors is highly variable being small and some malignant tumors, indicating low predictive and diagnostic value of cancer stem cell content in clinical practice. |
| format |
Article |
| author |
Lisyaniy, N.I. Stanetskaya, D.N. Lisyaniy, A.N. Belskaya, L.N. |
| author_facet |
Lisyaniy, N.I. Stanetskaya, D.N. Lisyaniy, A.N. Belskaya, L.N. |
| author_sort |
Lisyaniy, N.I. |
| title |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type |
| title_short |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type |
| title_full |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type |
| title_fullStr |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type |
| title_full_unstemmed |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type |
| title_sort |
content of stem tumor cd133⁺ cells in brain neoplasms of different histological type |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2017 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138544 |
| citation_txt |
Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type / N.I. Lisyaniy, D.N. Stanetskaya, A.N. Lisyaniy, L.N. Belskaya // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 219–223. — Бібліогр.: 26 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:18:06Z |
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