Adsorption-rheological properties of blood serum in lung cancer patients

Adsorption-rheological properties of blood serum in lung cancer patients

The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their associati...

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Бібліографічні деталі
Дата:2017
Автори: Dumanskiy, Y.V., Stoliarova, O.Y., Syniachenko, O.V., Giulmamedova, M.F., Potapov, Y.A.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138545
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Adsorption-rheological properties of blood serum in lung cancer patients / Y.V. Dumanskiy, O.Y. Stoliarova, O.V. Syniachenko, M.F. Giulmamedova, Y.A. Potapov // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 304–307. — Бібліогр.: 17 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1385452018-06-20T03:04:46Z Adsorption-rheological properties of blood serum in lung cancer patients Dumanskiy, Y.V. Stoliarova, O.Y. Syniachenko, O.V. Giulmamedova, M.F. Potapov, Y.A. Original contributions The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity). 2017 Article Adsorption-rheological properties of blood serum in lung cancer patients / Y.V. Dumanskiy, O.Y. Stoliarova, O.V. Syniachenko, M.F. Giulmamedova, Y.A. Potapov // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 304–307. — Бібліогр.: 17 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138545 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Dumanskiy, Y.V.
Stoliarova, O.Y.
Syniachenko, O.V.
Giulmamedova, M.F.
Potapov, Y.A.
Adsorption-rheological properties of blood serum in lung cancer patients
Experimental Oncology
description The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity).
format Article
author Dumanskiy, Y.V.
Stoliarova, O.Y.
Syniachenko, O.V.
Giulmamedova, M.F.
Potapov, Y.A.
author_facet Dumanskiy, Y.V.
Stoliarova, O.Y.
Syniachenko, O.V.
Giulmamedova, M.F.
Potapov, Y.A.
author_sort Dumanskiy, Y.V.
title Adsorption-rheological properties of blood serum in lung cancer patients
title_short Adsorption-rheological properties of blood serum in lung cancer patients
title_full Adsorption-rheological properties of blood serum in lung cancer patients
title_fullStr Adsorption-rheological properties of blood serum in lung cancer patients
title_full_unstemmed Adsorption-rheological properties of blood serum in lung cancer patients
title_sort adsorption-rheological properties of blood serum in lung cancer patients
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2017
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138545
citation_txt Adsorption-rheological properties of blood serum in lung cancer patients / Y.V. Dumanskiy, O.Y. Stoliarova, O.V. Syniachenko, M.F. Giulmamedova, Y.A. Potapov // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 304–307. — Бібліогр.: 17 назв. — англ.
series Experimental Oncology
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AT stoliarovaoy adsorptionrheologicalpropertiesofbloodseruminlungcancerpatients
AT syniachenkoov adsorptionrheologicalpropertiesofbloodseruminlungcancerpatients
AT giulmamedovamf adsorptionrheologicalpropertiesofbloodseruminlungcancerpatients
AT potapovya adsorptionrheologicalpropertiesofbloodseruminlungcancerpatients
first_indexed 2023-10-18T21:18:24Z
last_indexed 2023-10-18T21:18:24Z
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