Expression OF p53, p21WAF1/CIP1 , p16INK4A and Ki-67 proteins in serous ovarian tumors
Aim: The analysis of p53, p21WAF1/CIP1, p16INK4a and Ki-67 expression in serous ovarian carcinomas of different grade. Materials and Methods: In total, 43 ovarian adenocarcinomas and 8 non-altered ovarian epithelial tissues were immunohistochemically investigated for expression of Кі-67, р53, р21WAF...
Збережено в:
Дата: | 2007 |
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Автори: | , , , , , |
Формат: | Стаття |
Мова: | English |
Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2007
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Назва видання: | Experimental Oncology |
Теми: | |
Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138561 |
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Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
Цитувати: | Expression OF p53, p21WAF1/CIP1 , p16INK4A and Ki-67 proteins in serous ovarian tumors / L.G. Buchynska, I.P. Nesina, N.P. Yurchenko, O.O. Bilyk, V.N. Grinkevych, V.S. Svintitsky // Experimental Oncology. — 2007. — Т. 29, № 1. — С. 49-53. — Бібліогр.: 23 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of UkraineРезюме: | Aim: The analysis of p53, p21WAF1/CIP1, p16INK4a and Ki-67 expression in serous ovarian carcinomas of different grade. Materials and Methods: In total, 43 ovarian adenocarcinomas and 8 non-altered ovarian epithelial tissues were immunohistochemically investigated for expression of Кі-67, р53, р21WAF1/CIP1 and р16INK4a. Results: It has been shown that expression of Кі-67, р53, р21WAF1/CIP1 and р16INK4a in non-altered ovarian epithelial tissue is absent. Serous ovarian carcinomas are characterized by high proliferative activity (PI Кі-67 = 30.0 ± 0.3%), р53 and р16INK4a overexpression (LI is 40.3 ± 0.3% and 31.1 ± 0.6% respectively) and low expression of р21WAF1/CIP1 (LI = 6.8 ± 0.3%). The association between expression of these markers and ovarian tumor grade was defined: the maximal level of Кі-67, р53 and p16/INK4a and minimal of p21WAF1/CIP1 expression were observed in G3 tumors. So, low p21WAF1/CIP1 expression (LI < 7.0%) combined with р16INK4a overexpression is considered to be the factor for a poor prognosis in serous ovarian cancer. Conclusions: The present study has indicated that biomolecular markers of cell proliferation along with traditional clinical and morphologic characteristics can be used for differential diagnostics of ovarian tumors. |
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