SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population

SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population

A variable number of tandem repeats (VNTR) polymorphism in regulatory region of SMYD3 coding for histone methyltransferase has been shown to be associated with colorectal cancer, hepatocellular carcinoma (HCC), and breast cancer in Japanese population. Aim of the study is to investigate the potentia...

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Дата:2007
Автори: Wang, X.Q., Miao, X., Cai, Q., Garcia-Barcelo, M.M., Fan, S.T.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2007
Назва видання:Experimental Oncology
Теми:
Short communications
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138565
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population / X.Q. Wang, X. Miao, Q. Cai, M.M. Garcia-Barcelo, S.T. Fan // Experimental Oncology. — 2007. — Т. 29, № 1. — С. 71-73. — Бібліогр.: 7 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1385652018-06-20T03:10:49Z SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population Wang, X.Q. Miao, X. Cai, Q. Garcia-Barcelo, M.M. Fan, S.T. Short communications A variable number of tandem repeats (VNTR) polymorphism in regulatory region of SMYD3 coding for histone methyltransferase has been shown to be associated with colorectal cancer, hepatocellular carcinoma (HCC), and breast cancer in Japanese population. Aim of the study is to investigate the potential association between the functional SMYD3 tandem repeats polymorphism and HCC in Chinese population. Material and Methods: The case-control study included 200 HCC patients and 261 healthy controls. The VNTR polymorphism in the promoter of SMDY3 was genotyped by PCR and direct-sequencing analysis. Odds ratio and 95% confidence interval were used to estimate the association between the polymorphisms and risk of HCC. Results: The allele frequencies for SMYD3 2 and 3 repeats were 15.71% and 84.29% among controls; and 12.75%, and 87.25% among cases (P = 0.22). The odds ratio for 3/3 versus 2/2 and 2/3 genotypes was 1.30 (P = 0.18). The frequencies of 3 alleles were not increased with HCC stage increased (trend test, P = 0.45). Conclusion: SMYD3 polymorphism is not associated with the occurrence and metastasis of HCC in Chinese population. Известно, что полиморфизм тандемных повторов (VNTR) в регуляторном участке гена SMYD3,кодирующем метилтрансферазу гистонов, ассоциирован с развитием рака прямой кишки, карциномы печени (HCC) и рака молочной железы и является популяционно-зависимой характеристикой. Цель работы состояла в исследовании возможной связи междуVNTR Геном SMYD3 и развитием HCC у населения Китая. Материалы и методы: исследование типа “случай-контроль” проводили с участием 200 пациентов с HCC и 261 здорового донора. Полиморфизм VNTR в промоторной области гена SMDY3генотипировали методами PCR. Для оценки связи между полиморфизмом и риском развитияHCC использовали отношение шансов (OR) и 95% доверительные интервалы. Результаты: частота аллелей для повторов SMYD3 2 и 3 составила 15,71 и 84,29% в контрольной группе и 12,75 и 87,25% — в группе больных (P = 0,22). OR Генотипов 3/3 versus 2/2 и 2/3 составило 1,30 (P = 0.18). Частота 3 аллелей не возрастала при повышении стадии заболевания (P = 0,45). Выводы: полиморфизм гена SMYD3 не ассоциирован с развитием и метастазированием HCC у населения Китая. 2007 Article SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population / X.Q. Wang, X. Miao, Q. Cai, M.M. Garcia-Barcelo, S.T. Fan // Experimental Oncology. — 2007. — Т. 29, № 1. — С. 71-73. — Бібліогр.: 7 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138565 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Wang, X.Q.
Miao, X.
Cai, Q.
Garcia-Barcelo, M.M.
Fan, S.T.
SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
Experimental Oncology
description A variable number of tandem repeats (VNTR) polymorphism in regulatory region of SMYD3 coding for histone methyltransferase has been shown to be associated with colorectal cancer, hepatocellular carcinoma (HCC), and breast cancer in Japanese population. Aim of the study is to investigate the potential association between the functional SMYD3 tandem repeats polymorphism and HCC in Chinese population. Material and Methods: The case-control study included 200 HCC patients and 261 healthy controls. The VNTR polymorphism in the promoter of SMDY3 was genotyped by PCR and direct-sequencing analysis. Odds ratio and 95% confidence interval were used to estimate the association between the polymorphisms and risk of HCC. Results: The allele frequencies for SMYD3 2 and 3 repeats were 15.71% and 84.29% among controls; and 12.75%, and 87.25% among cases (P = 0.22). The odds ratio for 3/3 versus 2/2 and 2/3 genotypes was 1.30 (P = 0.18). The frequencies of 3 alleles were not increased with HCC stage increased (trend test, P = 0.45). Conclusion: SMYD3 polymorphism is not associated with the occurrence and metastasis of HCC in Chinese population.
format Article
author Wang, X.Q.
Miao, X.
Cai, Q.
Garcia-Barcelo, M.M.
Fan, S.T.
author_facet Wang, X.Q.
Miao, X.
Cai, Q.
Garcia-Barcelo, M.M.
Fan, S.T.
author_sort Wang, X.Q.
title SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
title_short SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
title_full SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
title_fullStr SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
title_full_unstemmed SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population
title_sort smyd3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a chinese population
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2007
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/138565
citation_txt SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population / X.Q. Wang, X. Miao, Q. Cai, M.M. Garcia-Barcelo, S.T. Fan // Experimental Oncology. — 2007. — Т. 29, № 1. — С. 71-73. — Бібліогр.: 7 назв. — англ.
series Experimental Oncology
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AT caiq smyd3tandemrepeatspolymorphismisnotassociatedwiththeoccurrenceandmetastasisofhepatocellularcarcinomainachinesepopulation
AT garciabarcelomm smyd3tandemrepeatspolymorphismisnotassociatedwiththeoccurrenceandmetastasisofhepatocellularcarcinomainachinesepopulation
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first_indexed 2023-10-18T21:18:46Z
last_indexed 2023-10-18T21:18:46Z
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