Molecular profiling and genomic microarrays in prostate cancer
In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss of balanced gene expression. A complete knowl...
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| Дата: | 2007 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2007
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138572 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Molecular profiling and genomic microarrays in prostate cancer / Ch. Golias, A. Charalabopoulos, D. Stagikas, X. Giannakopoulos, D. Peschos, A. Batistatou, N. Sofikitis, K. Charalabopoulos // Experimental Oncology. — 2007. — Т. 29, № 2. — С. 82-84. — Бібліогр.: 15 назв. — англ. |
Репозитарії
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irk-123456789-1385722020-10-11T00:36:20Z Molecular profiling and genomic microarrays in prostate cancer Golias, Ch. Charalabopoulos, A. Stagikas, D. Giannakopoulos, X. Peschos, D. Batistatou, A. Sofikitis, N. Charalabopoulos, K. Reviews In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss of balanced gene expression. A complete knowledge of the interaction between the genetic variability of the neoformation (tumor profiling) and the genetic variability of the host (inherited genome profiling), will be able to determine the better strategy against the cancer and the less toxicity for the patient. Alterations in the sequence of the hormone binding domain of the androgen receptor as well as mutations in some genes, determine radioresistance and resistance or sensitivity to some chemotherapeutic drugs. New therapies using monoclonal antibodies directed against specific extracellular binding domains of some receptors are based on molecular alterations observed in tumors. В обзоре обсуждается целесообразность применения геномных микрочипов для выявления рака предстательной железы. Рак является многоэтапным процессом мутаций в ключевых регуляторных генах и эпигенетических изменений, приводящих к утрате сбалансированной экспрессии генов. Фундаментальные знания о взаимосвязи между генетической вариабельностью опухолевых клеток (молекулярном профиле опухоли) и генетической вариабельностью хозяина (наследуемый геномный профиль) позволит выбрать наилучшую стратегию противоопухолевой терапии при низкой токсичности таковой. Изменения последовательности гормонсвязывающего домена рецептора андрогена наряду с мутациями некоторых генов определяют устойчивость к лучевой терапии и устойчивость или чувствительность к ряду химиопрепаратов. Новые виды терапии с использованием моноклональных антител против специфичных внеклеточных связывающих доменов ряда рецепторов основаны на данных о молекулярных особенностях новообразований. 2007 Article Molecular profiling and genomic microarrays in prostate cancer / Ch. Golias, A. Charalabopoulos, D. Stagikas, X. Giannakopoulos, D. Peschos, A. Batistatou, N. Sofikitis, K. Charalabopoulos // Experimental Oncology. — 2007. — Т. 29, № 2. — С. 82-84. — Бібліогр.: 15 назв. — англ. 1812-9269 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138572 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Golias, Ch. Charalabopoulos, A. Stagikas, D. Giannakopoulos, X. Peschos, D. Batistatou, A. Sofikitis, N. Charalabopoulos, K. Molecular profiling and genomic microarrays in prostate cancer Experimental Oncology |
| description |
In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss of balanced gene expression. A complete knowledge of the interaction between the genetic variability of the neoformation (tumor profiling) and the genetic variability of the host (inherited genome profiling), will be able to determine the better strategy against the cancer and the less toxicity for the patient. Alterations in the sequence of the hormone binding domain of the androgen receptor as well as mutations in some genes, determine radioresistance and resistance or sensitivity to some chemotherapeutic drugs. New therapies using monoclonal antibodies directed against specific extracellular binding domains of some receptors are based on molecular alterations observed in tumors. |
| format |
Article |
| author |
Golias, Ch. Charalabopoulos, A. Stagikas, D. Giannakopoulos, X. Peschos, D. Batistatou, A. Sofikitis, N. Charalabopoulos, K. |
| author_facet |
Golias, Ch. Charalabopoulos, A. Stagikas, D. Giannakopoulos, X. Peschos, D. Batistatou, A. Sofikitis, N. Charalabopoulos, K. |
| author_sort |
Golias, Ch. |
| title |
Molecular profiling and genomic microarrays in prostate cancer |
| title_short |
Molecular profiling and genomic microarrays in prostate cancer |
| title_full |
Molecular profiling and genomic microarrays in prostate cancer |
| title_fullStr |
Molecular profiling and genomic microarrays in prostate cancer |
| title_full_unstemmed |
Molecular profiling and genomic microarrays in prostate cancer |
| title_sort |
molecular profiling and genomic microarrays in prostate cancer |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2007 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138572 |
| citation_txt |
Molecular profiling and genomic microarrays in prostate cancer / Ch. Golias, A. Charalabopoulos, D. Stagikas, X. Giannakopoulos, D. Peschos, A. Batistatou, N. Sofikitis, K. Charalabopoulos // Experimental Oncology. — 2007. — Т. 29, № 2. — С. 82-84. — Бібліогр.: 15 назв. — англ. |
| series |
Experimental Oncology |
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