Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes
Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp wa...
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| Дата: | 2010 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2010
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138592 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. |
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irk-123456789-1385922018-06-20T03:04:15Z Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. Original contributions Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp was used for fullerenes C60 photoexcitation. Cytotoxicity was etermined by MTT assay. Changes in cell morphology were monitored by phase-contrast light microscopy. Results: fullerenes C60 exhibit cytotoxic effect against transformed T-lymphocytes when combined with UV/Vis irradiation (320–600 nm). Photoinduced effect was enhanced with the increasing of irradiation time period and C60 concentration, cell death was registered after 24 hours incubation. Fullerenes C60 photocytotoxicity against normal T-lymphocytes (thymocytes) was not observed. Conclusion: The present study suggests that pristine fullerenes C60 have the potential to be an effective photosensitizer and exhibit cytotoxic effect on transformed T-cells in vitro. 2010 Article Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138592 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes Experimental Oncology |
| description |
Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp was used for fullerenes C60 photoexcitation. Cytotoxicity was etermined by MTT assay. Changes in cell morphology were monitored by phase-contrast light microscopy. Results: fullerenes C60 exhibit cytotoxic effect against transformed T-lymphocytes when combined with UV/Vis irradiation (320–600 nm). Photoinduced effect was enhanced with the increasing of irradiation time period and C60 concentration, cell death was registered after 24 hours incubation. Fullerenes C60 photocytotoxicity against normal T-lymphocytes (thymocytes) was not observed. Conclusion: The present study suggests that pristine fullerenes C60 have the potential to be an effective photosensitizer and exhibit cytotoxic effect on transformed T-cells in vitro. |
| format |
Article |
| author |
Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. |
| author_facet |
Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. |
| author_sort |
Prylutska, S.V. |
| title |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_short |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_full |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_fullStr |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_full_unstemmed |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_sort |
photoinduced cytotoxic effect of fullerenes c60 on transformed t-lymphocytes |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2010 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138592 |
| citation_txt |
Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:18:07Z |
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2023-10-18T21:18:07Z |
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