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Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (A...

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Main Authors: Cherdyntseva, N.V., Gervas, P.A., Litvyakov, N.V., Stakcheeva, M.N., Ponomaryeva, A.A., Dobrodeev, A.Yu., Denisov, E.V., Belyavskaya, V.A., Choinzonov, E.L.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
Series:Experimental Oncology
Subjects:
Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138611
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spelling irk-123456789-1386112018-06-20T03:07:18Z Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression Cherdyntseva, N.V. Gervas, P.A. Litvyakov, N.V. Stakcheeva, M.N. Ponomaryeva, A.A. Dobrodeev, A.Yu. Denisov, E.V. Belyavskaya, V.A. Choinzonov, E.L. Original contributions Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment Lenth Polymorphism PCR. Results: We showed that combination of TP53 variant genotypes and XRCC1 variant genotype is associated with the increased lung cancer risk in younger, but not elderly, smokers. In contrast, wild allele combination increases lung cancer risk for individuals over the age of 60. Conclusion: Our data confirm antagonistic pleiotropy hypothesis indicating that p53 protects the organism against cancer early in life, but promoting aging phenotype, including late life cancer in older persons. 2010 Article Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138611 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
Experimental Oncology
description Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment Lenth Polymorphism PCR. Results: We showed that combination of TP53 variant genotypes and XRCC1 variant genotype is associated with the increased lung cancer risk in younger, but not elderly, smokers. In contrast, wild allele combination increases lung cancer risk for individuals over the age of 60. Conclusion: Our data confirm antagonistic pleiotropy hypothesis indicating that p53 protects the organism against cancer early in life, but promoting aging phenotype, including late life cancer in older persons.
format Article
author Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
author_facet Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
author_sort Cherdyntseva, N.V.
title Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_short Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_full Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_fullStr Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_full_unstemmed Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_sort age-related function of tumor suppressor gene tp53:contribution to cancer risk and progression
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2010
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138611
citation_txt Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:18:28Z
last_indexed 2023-10-18T21:18:28Z
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