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Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line

Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line

Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of d...

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Main Authors: Rusetskaya, N.V., Khariton, N., Yurchenko, O.V., Chekhun, V.F.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Series:Experimental Oncology
Subjects:
Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138616
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spelling irk-123456789-1386162018-06-20T03:08:20Z Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. Original contributions Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin. 2011 Article Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138616 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Rusetskaya, N.V.
Khariton, N.
Yurchenko, O.V.
Chekhun, V.F.
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
Experimental Oncology
description Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin.
format Article
author Rusetskaya, N.V.
Khariton, N.
Yurchenko, O.V.
Chekhun, V.F.
author_facet Rusetskaya, N.V.
Khariton, N.
Yurchenko, O.V.
Chekhun, V.F.
author_sort Rusetskaya, N.V.
title Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
title_short Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
title_full Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
title_fullStr Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
title_full_unstemmed Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
title_sort distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of mcf-7 line
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2011
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138616
citation_txt Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT rusetskayanv distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line
AT kharitonn distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line
AT yurchenkoov distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line
AT chekhunvf distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line
first_indexed 2023-10-18T21:18:28Z
last_indexed 2023-10-18T21:18:28Z
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