Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis
Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been...
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| Дата: | 2011 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138636 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1386362018-06-20T03:09:48Z Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. Short communications Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis. 2011 Article Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138636 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis Experimental Oncology |
| description |
Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis. |
| format |
Article |
| author |
Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. |
| author_facet |
Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. |
| author_sort |
Prylutska, S.V. |
| title |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_short |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_full |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_fullStr |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_full_unstemmed |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_sort |
pristine c60 fullerenes inhibit the rate of tumor growth and metastasis |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2011 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138636 |
| citation_txt |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:18:49Z |
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2023-10-18T21:18:49Z |
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