Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues

Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues

Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in...

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Бібліографічні деталі
Дата:2011
Автори: Kiyamova, R., Shyian, M., Lyzogubov, V.V., Usenko, V.S., Gout, T., Filonenko, V.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138654
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1386542018-06-20T03:08:37Z Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues Kiyamova, R. Shyian, M. Lyzogubov, V.V. Usenko, V.S. Gout, T. Filonenko, V. Original contributions Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in breast, lung and ovarian carcinomas. Intensity of NaPi2b protein expression was calculated with semiquantitative scores. Results: NaPi2b (MX35) protein expression was detected in breast, lung and ovarian cancer cells and adjacent normal tissue. We have shown that in contrast to ovarian tumors in breast and lung tumors NaPi2b expression is down regulated comparing to correspondent normal tissues. Conclusion: This study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers, which might be useful for understanding the mechanism of transport and maintenance of inorganic phosphate in cancer and normal cells, as well as for developing novel immunotherapeutic approaches based on MX35 monoclonal antibody. 2011 Article Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138654 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
Experimental Oncology
description Aim: To study the expression profile of the NaPi2b protein and its localization in breast, ovarian and lung cancer cells in relation to normal tissues adjacent to tumor. Methods: Immunohistochemical analysis with monoclonal antibody MX35 was applied for investigation of NaPi2b protein expression in breast, lung and ovarian carcinomas. Intensity of NaPi2b protein expression was calculated with semiquantitative scores. Results: NaPi2b (MX35) protein expression was detected in breast, lung and ovarian cancer cells and adjacent normal tissue. We have shown that in contrast to ovarian tumors in breast and lung tumors NaPi2b expression is down regulated comparing to correspondent normal tissues. Conclusion: This study provides the data on the pattern of NaPi2b expression and cellular localization in breast, lung and ovarian cancers, which might be useful for understanding the mechanism of transport and maintenance of inorganic phosphate in cancer and normal cells, as well as for developing novel immunotherapeutic approaches based on MX35 monoclonal antibody.
format Article
author Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
author_facet Kiyamova, R.
Shyian, M.
Lyzogubov, V.V.
Usenko, V.S.
Gout, T.
Filonenko, V.
author_sort Kiyamova, R.
title Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_short Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_full Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_fullStr Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_full_unstemmed Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues
title_sort immunohistochemical analysis of napi2b protein (mx35 antigen) expression and subcellular localization in human normal and cancer tissues
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2011
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138654
citation_txt Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues / R. Kiyamova, M. Shyian, V.V. Lyzogubov, V.S. Usenko, T. Gout, V. Filonenko // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 157-161. — Бібліогр.: 23 назв. — англ.
series Experimental Oncology
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AT shyianm immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT lyzogubovvv immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT usenkovs immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT goutt immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
AT filonenkov immunohistochemicalanalysisofnapi2bproteinmx35antigenexpressionandsubcellularlocalizationinhumannormalandcancertissues
first_indexed 2023-10-18T21:18:51Z
last_indexed 2023-10-18T21:18:51Z
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