Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient
Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may oc...
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| Дата: | 2011 |
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| Автори: | , , , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138666 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. |
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irk-123456789-1386662018-06-20T03:04:18Z Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. Short communications Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may occur, if the immune function is compromised. Aim: To present a PML case in a CLL patient after a long course of disease and treatment with fludarabine. JCV virus infection in this patient was proven both in brain biopsy material and blood. Methods: Patient with a nine-year history of CLL was hospitalized with the weakness in the right leg and left hand, tremors, speech difficulties. An MRI diagnosed infiltrative glial tumor of the left hemisphere, proliferating predominantly in the frontal lobe, more in the gyrus frontalis superior region. CNS tumor biopsy performed. Results: Morphology and immunoprofile of the lesion consistent with progressive multifocal leukoencephalopathy. The material from biopsy was diagnosed as positive for JCV DNA. JCV and HHV-7 genomic sequences were found in patient’s PBL DNA sample. In a plasma DNA sample, only genomic sequences were detected. Conclusion: The present case draws attention to the fact that the use of fludarabine and its combinations in CLL therapy increases the risk of JCV infection reactivation and development of serious complications like PML. 2011 Article Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138666 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient Experimental Oncology |
| description |
Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may occur, if the immune function is compromised. Aim: To present a PML case in a CLL patient after a long course of disease and treatment with fludarabine. JCV virus infection in this patient was proven both in brain biopsy material and blood. Methods: Patient with a nine-year history of CLL was hospitalized with the weakness in the right leg and left hand, tremors, speech difficulties. An MRI diagnosed infiltrative glial tumor of the left hemisphere, proliferating predominantly in the frontal lobe, more in the gyrus frontalis superior region. CNS tumor biopsy performed. Results: Morphology and immunoprofile of the lesion consistent with progressive multifocal leukoencephalopathy. The material from biopsy was diagnosed as positive for JCV DNA. JCV and HHV-7 genomic sequences were found in patient’s PBL DNA sample. In a plasma DNA sample, only genomic sequences were detected. Conclusion: The present case draws attention to the fact that the use of fludarabine and its combinations in CLL therapy increases the risk of JCV infection reactivation and development of serious complications like PML. |
| format |
Article |
| author |
Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. |
| author_facet |
Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. |
| author_sort |
Lejniece, S. |
| title |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_short |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_full |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_fullStr |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_full_unstemmed |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_sort |
progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2011 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138666 |
| citation_txt |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:13Z |
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2023-10-18T21:19:13Z |
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